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Volume 2 (2002), Pages 89-95
Mini-Review Article

The Role of High Density Lipoproteins in Thrombosis

University of Pennsylvania School of Medicine, Department of Medicine, Philadelphia, USA

Received 10 October 2001; Revised 21 November 2001; Accepted 27 November 2001

Copyright © 2002 Marina Cuchel and Daniel J. Rader.


Lipids and lipoproteins, as well as factors involved in hemostasis and thrombosis, play a central role in the pathogenesis of cardio- and cerebrovascular disease. In recent years it has become clear that a strong association exists between coagulation factors and plasma lipoproteins. Anionic phospholipids are necessary for the optimal activity of both pro- and anticoagulant enzymatic complexes. Cell membranes have traditionally been considered to provide the essential lipid-containing surfaces. However, in light of recent studies, plasma lipoproteins are also believed to provide appropriate surfaces to support coagulation. While triglyceride-rich lipoproteins and oxidized low-density lipoproteins are associated with a procoagulant profile, high-density lipoproteins (HDL) may have an anticoagulant effect. This paper reviews scientific data on the potential role of HDL as modulator of thrombotic processes.