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Volume 2, Pages 483-491
Mini-Review Article

Cloning Approaches for Identifying Aging and Longevity-Related Genes in Mammals

National Hellenic Research Foundation, Institute of Biological Research and Biotechnology, 48 Vas. Constantinou Ave., Athens 11635, Greece

Received 29 October 2001; Accepted 4 January 2002

Copyright © 2002 Davina C. Simoes and Efstathios S. Gonos.


Aging is a phenomenon that affects nearly all animal species. Several studies using different systems have identified a number of processes thought to contribute to the aging phenotype. Many differentially expressed genes have been implicated, but the mechanisms governing mammalian aging (and longevity) are not yet fully understood, and the list of concerned genes is still incomplete and fragmented. Different approaches have been used to clone aging and longevity-related genes. In this article we review these cloning techniques and discuss their advantages and limitations. Further research on the function of these genes as well as the network of their protein products will give better insight into the aging process as a whole and its associated pathologies.