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TheScientificWorldJOURNAL
Volume 3, Pages 265-278
http://dx.doi.org/10.1100/tsw.2003.02
Methods Paper

The Use of Spreadsheets for Pharmacokinetic Simulations

127 Church Green Road, Bletchley, Milton Keynes, Buckinghamshire, MK3 6DE, UK

Academic Editor: Geoff Hanlon

Copyright © 2003 Joseph Chamberlain.

Abstract

The use of simple spreadsheets is described to create simulations of complex pharmacokinetic phenomena. The basics of spreadsheets are first described and are developed to demonstrate classical pharmacokinetics without the use of differential or integral calculus. Using standard spreadsheet commands, the technique is shown to be applicable to the full range of advanced pharmacokinetic simulations. Demonstrations of the effect of a variety of physiological eventualities are included to show the versatility of the technique. The technique is very simple to use and is always in the complete control of the modeller.