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TheScientificWorldJOURNAL
Volume 3, Pages 1332-1343
http://dx.doi.org/10.1100/tsw.2003.121
Research Article

Differences Between Lovastatin and Simvastatin Hydrolysis in Healthy Male and Female Volunteers: Gut Hydrolysis of Lovastatin is Twice that of Simvastatin

Institute for Anaesthesiology, University Medical Centre Nijmegen Sint Radboud, Nijmegen, The Netherlands

Copyright © 2003 Tom B. Vree et al.

Citations to this Article [15 citations]

The following is the list of published articles that have cited the current article.

  • Nicoline Jochmann, Edeltraut Garbe, Gert Baumann, Karl Stangl, and Verena Stangl, “Female-specific aspects in the pharmacotherapy of chronic cardiovascular diseases,” European Heart Journal, vol. 26, no. 16, pp. 1585–1595, 2005. View at Publisher · View at Google Scholar
  • Ping Li, Patrick S. Callery, Liang-Shang Gan, and Suresh K. Balani, “Esterase inhibition attribute of grapefruit juice leading to a new drug interaction,” Drug Metabolism And Disposition, vol. 35, no. 7, pp. 1023–1031, 2007. View at Publisher · View at Google Scholar
  • Igor Karp, Shun-Fu Chen, and Louise Pilote, “Sex differences in the effectiveness of statins after myocardial infarction,” Canadian Medical Association Journal, vol. 176, no. 3, pp. 333–338, 2007. View at Publisher · View at Google Scholar
  • Christopher Kohl, “The Importance of Gut Wall Metabolism in Determining Drug Bioavailability,” Drug Bioavailability, pp. 333–357, 2009. View at Publisher · View at Google Scholar
  • Bishwajit Ganguly, Manoj K. Kesharwani, Marija Matković, Nikola Basarić, Ajeet Singh, and Kata Mlinarić-Majerski, “Hydrolysis and retro-aldol cleavage of ethyl threo-2-(1-adamantyl)-3-hydroxybutyrate: competing reactions,” Journal of Physical Organic Chemistry, vol. 24, no. 7, pp. 578–587, 2010. View at Publisher · View at Google Scholar
  • Sarah Egert, and Gerald Rimbach, “Which Sources of Flavonoids: Complex Diets or Dietary Supplements?,” Advances In Nutrition, vol. 2, no. 1, pp. 8–14, 2011. View at Publisher · View at Google Scholar
  • Rodolfo Gatto, and Neelima B. Chauhan, “Restoration of cognitive deficits after statin feeding in TBI,” Restorative Neurology and Neuroscience, vol. 29, no. 1, pp. 23–34, 2011. View at Publisher · View at Google Scholar
  • Sevtap Savas, David O. Azorsa, Hamdi Jarjanazi, Irada Ibrahim-Zada, Meredith C. Henderson, Yun Hee Choi, Irma M. Gonzales, Shilpi Arora, Laurent Briollais, Hilmi Ozcelik, and Sukru Tuzmen, “NCI60 cancer cell line panel data and RNAi analysis help identify EAF2 as a modulator of simvastatin and lovastatin response in HCT-116 cells,” PLoS ONE, vol. 6, no. 4, 2011. View at Publisher · View at Google Scholar
  • Stefano Omboni, Ettore Malacco, Jean-Michel Mallion, Massimo Volpe, and Alberto Zanchetti, “Twenty-four hour and early morning blood pressure control of olmesartan vs. ramipril in elderly hypertensive patients,” Journal of Hypertension, vol. 30, no. 7, pp. 1468–1477, 2012. View at Publisher · View at Google Scholar
  • Stephan Riedmaier, and Ulrich M. Zanger, “Cardiovascular Drugs,” Metabolism of Drugs and Other Xenobiotics, pp. 331–363, 2012. View at Publisher · View at Google Scholar
  • S. Casey Laizure, Vanessa Herring, Zheyi Hu, Kevin Witbrodt, and Robert B. Parker, “The Role of Human Carboxylesterases in Drug Metabolism: Have We Overlooked Their Importance?,” Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, vol. 33, no. 2, pp. 210–222, 2013. View at Publisher · View at Google Scholar
  • Weihong Yang, Hongpong Xu, Yanliang Song, Xiaofei Wang, Xinwei Ren, Dengzhi Zhao, Yaoxin Cai, Shengjun Zhang, Jianmin Huang, Li-Rong Zhang, Tianyi Zhang, and Ming Zuo, “Pharmacokinetics of simvastatin lactone and its active metabolite simvastatin hydroxy acid in healthy Chinese male and female volunteers,” International Journal of Clinical Pharmacology and Therapeutics, vol. 52, no. 2, pp. 151–158, 2014. View at Publisher · View at Google Scholar
  • Chiara Pavanello, and Giuliana Mombelli, “Considering gender in prescribing statins: what do physicians need to know?,” Clinical Lipidology, 2015. View at Publisher · View at Google Scholar
  • Jian Shi, Xinwen Wang, Rachel F. Eyler, Yan Liang, Li Liu, Bruce A. Mueller, and Hao-Jie Zhu, “Association of Oseltamivir Activation with Gender and Carboxylesterase 1 Genetic Polymorphisms,” Basic & Clinical Pharmacology & Toxicology, 2016. View at Publisher · View at Google Scholar
  • Guilian Zhao, Mei Liu, Xiujun Wu, Guofei Li, Feng Qiu, Jingkai Gu, and Limei Zhao, “ Effect of polymorphisms in CYP3A4, PPARA, NR1I2, NFKB1, ABCG2 and SLCO1B1 on the pharmacokinetics of lovastatin in healthy Chinese volunteers ,” Pharmacogenomics, vol. 18, no. 1, pp. 65–75, 2017. View at Publisher · View at Google Scholar