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Volume 4, Pages 1-8
Review Article

Adenosine Receptors and Wound Healing

Department of Pathology, New York University School of Medicine, New York, 10016, USA

Received 28 August 2003; Revised 5 December 2003; Accepted 21 December 2003

Academic Editor: Edward J. Goetzl

Copyright © 2004 Bruce N. Cronstein.


Recent studies have demonstrated that application of topical adenosine A2A receptor agonists promotes more rapid wound closure and clinical studies are currently underway to determine the utility of topical A2A adenosine receptor agonists in the therapy of diabetic foot ulcers. The effects of adenosine A2A receptors on the cells and tissues of healing wounds have only recently been explored. We review here the known effects of adenosine A2A receptor occupancy on the cells involved in wound healing.