The Scientific World Journal

The Scientific World Journal / 2004 / Article
Special Issue

Selected Papers in Biomedicine for Research and Development

View this Special Issue

Research Article | Open Access

Volume 4 |Article ID 720301 | https://doi.org/10.1100/tsw.2004.210

David F.V. Lewis, "Hydrogen Bonding in Human P450-Substrate Interactions: A Major Contribution to Binding Affinity", The Scientific World Journal, vol. 4, Article ID 720301, 9 pages, 2004. https://doi.org/10.1100/tsw.2004.210

Hydrogen Bonding in Human P450-Substrate Interactions: A Major Contribution to Binding Affinity

Academic Editor: Joseph Chamberlain
Received12 Nov 2004
Revised01 Dec 2004
Accepted10 Dec 2004

Abstract

The importance of hydrogen bonding, a relatively strong intermolecular force of attraction between molecules in biological systems, is discussed in the respect of P450 substrate affinity towards one or more of the human P450 enzymes that are generally associated with drug and other xenobiotic metabolism. It is shown that calculation of hydrogen bond distances and energies based on simple empirical relationships provide values that agree closely with experimental findings. It is thus possible to estimate the hydrogen bond contribution to P450 enzyme-substrate binding affinity based on modelled interactions and by use of these relatively simple formulae, particularly when employed in conjunction with substrate-lipophilicity relationships.


More related articles

 PDF Download Citation Citation
 Order printed copiesOrder
Views138
Downloads428
Citations

Related articles