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TheScientificWorldJOURNAL
Volume 6 (2006), Pages 1862-1880
http://dx.doi.org/10.1100/tsw.2006.316
Review Article

Formation of the Ventricles

UCL Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK

Received 2 March 2006; Revised 6 April 2006; Accepted 6 April 2006

Academic Editor: Robert H. Anderson

Copyright © 2006 Catherine A. Risebro and Paul R. Riley.

Abstract

The formation of the ventricles of the heart involves numerous carefully regulated temporal events, including the initial specification and deployment of ventricular progenitors, subsequent growth and maturation of the ventricles through “ballooning” of chamber myocardium, the emergence of trabeculations, the generation of the compact myocardium, and the formation of the interventricular septum. Several genes have been identified through studies on mouse knockout and transgenic models, which have contributed to our understanding of the molecular events governing these developmental processes. Interpretation of these studies highlights the fact that even the smallest perturbation at any stage of ventricular development may lead to cardiac malformations that result in either early embryonic mortality or a manifestation of congenital heart disease.