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TheScientificWorldJOURNAL
Volume 6, Pages 908-917
http://dx.doi.org/10.1100/tsw.2006.179
Review Article

Diabetes, Inflammation, Proinflammatory Cytokines, and Diabetic Nephropathy

1Nephrology Service, University Hospital Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain
2Canarian Institute for Biomedical Research, University Hospital Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain
3Spanish National Research Council, Madrid, Spain

Received 19 June 2006; Revised 12 July 2006; Accepted 27 July 2006

Academic Editor: Daniel Batlle

Copyright © 2006 Juan F. Navarro and Carmen Mora.

Abstract

Diabetes and its complications have become a public health problem. Diabetic nephropathy is the main cause of renal failure. In spite of our higher knowledge on this complication, the intimate mechanisms leading to the development and progression of renal injury are not yet fully known. Activated innate immunity and inflammation are relevant factors in the pathogenesis of diabetes. Moreover, inflammation, and more specifically proinflammatory cytokines and other molecules with a relevant role within the inflammatory process, may be critical factors in the development of microvascular diabetic complications, including nephropathy. This new pathogenic perspective may lead to important new therapeutic considerations and new therapeutic goals for the treatment of diabetic nephropathy.