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Volume 6 (2006), Pages 116-121
Mini-Review Article

Androgen Excess Disorders in Women: The Severe Insulin-Resistant Hyperandrogenic Syndrome, HAIR-AN

Department of Pediatrics, University of Kentucky College of Medicine, Lexington, KY 40536, USA

Received 1 December 2005; Revised 25 December 2005; Accepted 26 December 2005

Academic Editor: Joav Merrick

Copyright © 2006 Kristin M. Rager and Hatim A. Omar.


HAIR-AN syndrome (hyperandrogenism, insulin resistance, acanthosis nigricans) is a subset of the polycystic ovary syndrome, where the patients demonstrate severe insulin resistance. It is theorized that both genetic and environmental factors, such as obesity, give rise to the development of HAIR-AN. Diagnosis is primarily clinical, with laboratory values lending further support. Treatment is aimed at decreasing insulin resistance, regulating ovulation, and decreasing acne, acanthosis nigricans, and hirsutism.