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Volume 6, Pages 1109-1113
Review Article

Collagen Fibril Diameter in Relation to Bone Site and to Calcium/Phosphorus Ratio

Laboratory of Medical Physics, Medical School, Ioannina University, 45110 Ioannina, Greece

Received 15 June 2006; Revised 8 August 2006; Accepted 23 August 2006

Academic Editor: Vittoria Ottani

Copyright © 2006 Panagiotis Berillis et al.


The collagen fibril diameter was measured in cortical bone samples from the femoral neck, rear and front tibia of female and male rats and rabbits using electron microscopy analysis. In most cases, statistically significant differences in mean fibril diameter values between different bone sites were detected. The order of magnitude for the above structural parameter was the same for both genders in both experimental species. In rats, the greatest mean diameter value was that for the femoral, while in rabbits, the one for the rear tibia demonstrating a dependence on bone use and life style. An important aspect was the agreement between these observations and the mean values for Ca/P ratio, as observed in previous experiments, in the same bone sites and animals. Collagen fibril diameter and Ca/P ratio can both serve as indexes of bone quality.