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Volume 7, Pages 1348-1358
Review Article

Cytokine-Leukotriene Receptor Interactions

Immunology Division, Department of Pediatrics, Faculty of Medicine, Université de Sherbrooke, Sherbrooke QC, J1H 5N4, Canada

Received 22 January 2007; Revised 12 June 2007; Accepted 2 July 2007

Academic Editor: Charles Brink

Copyright © 2007 Marek Rola-Pleszczynski and Jana Stankova.


Biochemical and pharmacological studies have identified the structure of leukotrienes, the pathways that lead to their synthesis, and the signaling events they trigger when they interact with their cognate receptors. A privileged interaction exists between these lipid mediators and another group of molecules essential for inflammation and immune modulation, namely, cytokines. Whereas leukotrienes can trigger the synthesis and release of selected cytokines in distinct cell populations, many cytokines can affect cellular responsiveness to leukotrienes by modulating leukotriene receptor expression. As we progressively begin to unravel these complex interactions, new areas of cell-cell communication and eventual therapeutic interventions will emerge.