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Volume 7, Pages 364-371
Review Article

Anesthetic Related Advances with Cyclodextrins

University of North Florida, Jacksonville, FL, USA

Received 1 October 2006; Accepted 15 February 2007

Academic Editor: John O'Donnell

Copyright © 2007 Mark Welliver and John McDonough.


Cyclodextrins encapsulate and electrostatically bind to lipophilic molecules. The exterior of cyclodextrins are water-soluble and maintain aqueous solubility despite encapsulation of non-aqueous soluble molecules. This unique ability to encapsulate lipophilic molecules and maintain water solubility confers numerous pharmacologic advantages for both drug delivery and removal. Cyclodextrins, a component part of supramolecular chemistry, may be in its infancy of anesthetic application but recent advances have been described as novel and revolutionary. A review of current research coupled with an understanding of cyclodextrin properties is necessary to fully appreciate the current uses and future potentials of these unique molecules.