The Scientific World Journal

The Scientific World Journal / 2007 / Article
Special Issue

Novel Targets in Shock

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Review Article | Open Access

Volume 7 |Article ID 408423 | 80 pages | https://doi.org/10.1100/tsw.2007.139

Pea Seedling Histaminase as a Novel Therapeutic Approach to Anaphylactic and Inflammatory Disorders

Academic Editor: Salvatorre Cuzzocrea
Received08 Nov 2006
Revised03 May 2007
Accepted14 May 2007

Abstract

Amine oxidases (AOs) are ubiquitous enzymes involved in the metabolism of biogenic amines. Copper AOs (Cu-AOs) catalyze the oxidative deamination of primary amine groups of several biogenic amines, such as putrescine, cadaverine, and histamine. In the present review, the effects of a plant amine oxidase (Cu-AO, histaminase, EC1.4.3.6) purified from pea seedlings in the modulation of IgE-mediated allergic reactions, and in the prevention of cardiac and splachnic postischemic reperfusion damage are reported.

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