Novel Targets in ShockView this Special Issue
Review Article | Open Access
Emanuela Masini, Danielle Bani, Cosimo Marzocca, Mircea Alexandru Mateescu, Pier Francesco Mannaioni, Rodolfo Federico, Bruno Mondovì, "Pea Seedling Histaminase as a Novel Therapeutic Approach to Anaphylactic and Inflammatory Disorders", The Scientific World Journal, vol. 7, Article ID 408423, 80 pages, 2007. https://doi.org/10.1100/tsw.2007.139
Pea Seedling Histaminase as a Novel Therapeutic Approach to Anaphylactic and Inflammatory Disorders
Amine oxidases (AOs) are ubiquitous enzymes involved in the metabolism of biogenic amines. Copper AOs (Cu-AOs) catalyze the oxidative deamination of primary amine groups of several biogenic amines, such as putrescine, cadaverine, and histamine. In the present review, the effects of a plant amine oxidase (Cu-AO, histaminase, EC18.104.22.168) purified from pea seedlings in the modulation of IgE-mediated allergic reactions, and in the prevention of cardiac and splachnic postischemic reperfusion damage are reported.