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Special Issue

Novel Targets in Shock

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Review Article | Open Access

Volume 7 |Article ID 408423 | 80 pages | https://doi.org/10.1100/tsw.2007.139

Pea Seedling Histaminase as a Novel Therapeutic Approach to Anaphylactic and Inflammatory Disorders

Emanuela Masini,1 Danielle Bani,2 Cosimo Marzocca,1 Mircea Alexandru Mateescu,3 Pier Francesco Mannaioni,1 Rodolfo Federico,4 and Bruno Mondovì5

1Department of Preclinical and Clinical Pharmacology, University of Florence, Italy

2Department of Anatomy, Histology and Forensic Medicine, Section of Histology, University of Florence, Italy

3Department of Chemistry and Biochemistry, Université du Québec à Montréal, Montreal (Quebec), Canada

4Department of Biology, University of Rome, Italy

5Department of Biochemical Sciences “A. Rossi Fanelli”, Rome University “La Sapienza”, Rome, Italy

Academic Editor: Salvatorre Cuzzocrea
Received08 Nov 2006
Revised03 May 2007
Accepted14 May 2007

Abstract

Amine oxidases (AOs) are ubiquitous enzymes involved in the metabolism of biogenic amines. Copper AOs (Cu-AOs) catalyze the oxidative deamination of primary amine groups of several biogenic amines, such as putrescine, cadaverine, and histamine. In the present review, the effects of a plant amine oxidase (Cu-AO, histaminase, EC1.4.3.6) purified from pea seedlings in the modulation of IgE-mediated allergic reactions, and in the prevention of cardiac and splachnic postischemic reperfusion damage are reported.

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