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Volume 7, Pages 146-154
Mini-Review Article

Role of microRNA Pathway in Mental Retardation

Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA

Received 26 June 2007; Revised 16 July 2007; Accepted 17 July 2007

Academic Editors: D. Shurtleff and S. Ferre

Copyright © 2007 Abrar Qurashi et al.


Deficits in cognitive functions lead to mental retardation (MR). Understanding the genetic basis of inherited MR has provided insights into the pathogenesis of MR. Fragile X syndrome is one of the most common forms of inherited MR, caused by the loss of functional Fragile X Mental Retardation Protein (FMRP).

MicroRNAs (miRNAs) are endogenous, single-stranded RNAs between 18 and 25 nucleotides in length, which have been implicated in diversified biological pathways. Recent studies have linked the miRNA pathway to fragile X syndrome. Here we review the role of the miRNA pathway in fragile X syndrome and discuss its implication in MR in general.