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TheScientificWorldJOURNAL
Volume 7 (2007), Pages 146-154
http://dx.doi.org/10.1100/tsw.2007.208
Mini-Review Article

Role of microRNA Pathway in Mental Retardation

Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA

Received 26 June 2007; Revised 16 July 2007; Accepted 17 July 2007

Academic Editors: D. Shurtleff and S. Ferre

Copyright © 2007 Abrar Qurashi et al.

Abstract

Deficits in cognitive functions lead to mental retardation (MR). Understanding the genetic basis of inherited MR has provided insights into the pathogenesis of MR. Fragile X syndrome is one of the most common forms of inherited MR, caused by the loss of functional Fragile X Mental Retardation Protein (FMRP).

MicroRNAs (miRNAs) are endogenous, single-stranded RNAs between 18 and 25 nucleotides in length, which have been implicated in diversified biological pathways. Recent studies have linked the miRNA pathway to fragile X syndrome. Here we review the role of the miRNA pathway in fragile X syndrome and discuss its implication in MR in general.