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TheScientificWorldJOURNAL
Volume 7, Pages 1413-1421
http://dx.doi.org/10.1100/tsw.2007.200
Review Article

The Role of Leukotriene Receptor Signaling in Inflammation and Cancer

Cell and Experimental Pathology, Department of Laboratory Medicine, Lund University, Malmo University Hospital, SE-205 02 Malmo, Sweden

Received 22 January 2007; Revised 2 July 2007; Accepted 11 July 2007

Academic Editor: Charles Brink

Copyright © 2007 Ramin Massoumi and Anita Sjölander.

Abstract

Leukotrienes (LTs) and prostaglandins (PGs) are metabolites of arachidonic acid that play major roles in various inflammatory conditions. The release of these mediators, by cells recruited to or present at the site of inflammation, modulate/influence the magnitude of the inflammatory response. A better understanding of eicosanoids and how their receptors trigger intracellular signaling during inflammatory conditions is helping to elucidate the well-known connection between chronic inflammatory disease and neoplastic transformation. In the current review, we summarize the role of LTs and PGs in chronic inflammation and, in particular, we focus on recent insights into the role of CysLT1 receptor signaling pathway. In addition, we delineate how continuous CysLT1 receptor activation and signaling can increase cell survival and proliferation as important early steps toward oncogenicity.