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TheScientificWorldJOURNAL
Volume 8, Pages 1119-1147
http://dx.doi.org/10.1100/tsw.2008.140
Review

Cytokines and Myelination in the Central Nervous System

1Center for Neuroscience Research, Children's Research Institute, Washington, DC, USA
2Department of Neonatology, Campus Virchow Klinikum, Charite Universitatsmedizin, Berlin, Germany

Received 4 June 2008; Revised 7 October 2008; Accepted 10 October 2008

Academic Editor: George Siegel

Copyright © 2008 Thomas Schmitz and Li-Jin Chew.

Citations to this Article [78 citations]

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  • Xiangning Chen, Cuie Sun, Qi Chen, F. Anthony O'Neill, Dermot Walsh, Ayman H. Fanous, Kodavali V. Chowdari, Vishwajit L. Nimgaonkar, Adrian Scott, Sibylle G. Schwab, Dieter B. Wildenauer, Ronglin Che, Wei Tang, Yongyong Shi, Lin He, Xiong-jian Luo, Bing Su, Todd L. Edwards, Zhongming Zhao, and Kenneth S. Kendler, “Apoptotic Engulfment Pathway and Schizophrenia,” Plos One, vol. 4, no. 9, 2009. View at Publisher · View at Google Scholar
  • Hans-Gert Bernstein, Johann Steiner, and Bernhard Bogerts, “Glial cells in schizophrenia: pathophysiological significance and possible consequences for therapy,” Expert Review of Neurotherapeutics, vol. 9, no. 7, pp. 1059–1071, 2009. View at Publisher · View at Google Scholar
  • Peng Ding, Li-Ping Xue, Zhi-Yong Yang, Chong-Qian Wang, Jia-Hu Wang, Zhong-Tang Feng, and Eng-Ang Ling, “Chemokine stromal cell-derived factor-1 and its receptor CXCR4 mediate migration of marrow stromal cells into the lesion site of completely transected spinal cord,” Journal of Clinical Rehabilitative Tissue Engineering Research, vol. 13, no. 27, pp. 5380–5384, 2009. View at Publisher · View at Google Scholar
  • Staci D. Bilbo, and Jaclyn M. Schwarz, “Early-life programming of later-life brain and behavior: a critical role for the immune system,” Frontiers In Behavioral Neuroscience, vol. 3, 2009. View at Publisher · View at Google Scholar
  • Espen J. Walker, and Gary A. Rosenberg, “Divergent role for MMP-2 in myelin breakdown and oligodendrocyte death following transient global ischemia,” Journal of Neuroscience Research, pp. NA–NA, 2009. View at Publisher · View at Google Scholar
  • Antoinette Defaux, Marie-Gabrielle Zurich, Paul Honegger, and Florianne Monnet-Tschudi, “Inflammatory responses in aggregating rat brain cell cultures subjected to different demyelinating conditions,” Brain Research, vol. 1353, pp. 213–224, 2010. View at Publisher · View at Google Scholar
  • Tobias D. Merson, Michele D. Binder, and Trevor J. Kilpatrick, “Role of Cytokines as Mediators and Regulators of Microglial Activity in Inflammatory Demyelination of the CNS,” Neuromolecular Medicine, vol. 12, no. 2, pp. 99–132, 2010. View at Publisher · View at Google Scholar
  • Florian Rieder, Piero Biancani, Karen Harnett, Lisa Yerian, and Gary W. Falk, “Inflammatory mediators in gastroesophageal reflux disease: impact on esophageal motility, fibrosis, and carcinogenesis,” American Journal Of Physiology-Gastrointestinal And Liver Physiology, vol. 298, no. 5, pp. G571–G581, 2010. View at Publisher · View at Google Scholar
  • B. M. Segal, B. A. Mueller, X. Zhu, R. Prosser, B. Pogatchnik, E. Holker, A. F. Carpenter, and K. O. Lim, “Disruption of brain white matter microstructure in primary Sjogren's syndrome: evidence from diffusion tensor imaging,” Rheumatology, vol. 49, no. 8, pp. 1530–1539, 2010. View at Publisher · View at Google Scholar
  • Tian-Ming Yuan, Yi Sun, Can-Yang Zhan, and Hui-Min Yu, “Intrauterine infection/inflammation and perinatal brain damage: Role of glial cells and Toll-like receptor signaling,” Journal Of Neuroimmunology, vol. 229, no. 1-2, pp. 16–25, 2010. View at Publisher · View at Google Scholar
  • N. G. Gorovenko, Z. I. Rossokha, S. V. Podolskaya, V. I. Pokhylko, and G. A. Lundberg, “The Role of Genetic Determinant in the Development of Severe Perinatal Asphyxia,” Cytology And Genetics, vol. 44, no. 5, pp. 294–299, 2010. View at Publisher · View at Google Scholar
  • Dong-Hyuk Park, David J. Eve, Yong-Gu Chung, and Paul R. Sanberg, “Regenerative Medicine for Neurological Disorders,” Thescientificworldjournal, vol. 10, pp. 470–489, 2010. View at Publisher · View at Google Scholar
  • Joyce A. Benjamins, Liljana Nedelkoska, Robert P. Lisak, John H. Hannigan, and Robert J. Sokol, “Cytokines Reduce Toxic Effects of Ethanol on Oligodendroglia,” Neurochemical Research, vol. 36, no. 9, pp. 1677–1686, 2011. View at Publisher · View at Google Scholar
  • Staci D. Bilbo, Susan H. Smith, and Jaclyn M. Schwarz, “A Lifespan Approach to Neuroinflammatory and Cognitive Disorders: A Critical Role for Glia,” Journal of Neuroimmune Pharmacology, vol. 7, no. 1, pp. 24–41, 2011. View at Publisher · View at Google Scholar
  • David J. Bond, Donna J. Lang, Melissa M. Noronha, Mauricio Kunz, Ivan J. Torres, Wayne Su, William G. Honer, Raymond W. Lam, and Lakshmi N. Yatham, “The association of elevated body mass index with reduced brain volumes in first-episode mania,” Biological Psychiatry, vol. 70, no. 4, pp. 381–387, 2011. View at Publisher · View at Google Scholar
  • J.M. Loftis, “Sertoli cell therapy: A novel possible treatment strategy for treatment-resistant major depressive disorder,” Medical Hypotheses, vol. 77, no. 1, pp. 35–42, 2011. View at Publisher · View at Google Scholar
  • Tadamune Kinjo, Shouichi Ohga, Masayuki Ochiai, Satoshi Honjo, Tamami Tanaka, Yasushi Takahata, Kenji Ihara, and Toshiro Hara, “Serum chemokine levels and developmental outcome in preterm infants,” Early Human Development, vol. 87, no. 6, pp. 439–443, 2011. View at Publisher · View at Google Scholar
  • Barbara M Segal, and Bryon A Mueller, “Cognitive disorders and brain MRI correlations in primary Sjögren’s syndrome: unlocking the secret of cognitive symptoms,” International Journal of Clinical Rheumatology, vol. 6, no. 1, pp. 35–45, 2011. View at Publisher · View at Google Scholar
  • Jinnan Liu, Jiaming Liu, Yi Zhou, Siyue Li, Yi Li, Xingbo Song, Jun Wang, Lanlan Wang, and Binwu Ying, “Association Between Promoter Variants of Interleukin-18 and Schizophrenia in a Han Chinese Population,” DNA and Cell Biology, vol. 30, no. 11, pp. 913–917, 2011. View at Publisher · View at Google Scholar
  • Geon-Ho Jahng, Songfan Xu, Micheal W. Weiner, Dieter J. Meyerhoff, Seungjoon Park, and Norbert Schuff, “DTI studies in patients with Alzheimer's disease, mild cognitive impairment, or normal cognition with evaluation of the intrinsic background gradients,” Neuroradiology, vol. 53, no. 10, pp. 749–762, 2011. View at Publisher · View at Google Scholar
  • Donard S. Dwyer, and Parrin Patterson, “Protection Against Neuroinflammation by Promoting Co-activation of G Protein– Growth Factor Signaling and Metabolic Flexibility in the Brain,” Neuroinflammation, pp. 325–346, 2011. View at Publisher · View at Google Scholar
  • Janine Walter, Silke D Honsek, Sebastian Illes, Jennifer M Wellen, Hans-Peter Hartung, Christine R Rose, and Marcel Dihné, “A new role for interferon gamma in neural stem/precursor cell dysregulation,” Molecular Neurodegeneration, vol. 6, no. 1, pp. 18, 2011. View at Publisher · View at Google Scholar
  • Andrea Escelsior, Michele Fornaro, Giulio Rocchi, and Matteo Martino, “Immunomodulation Mechanism of Antidepressants: Interactions between Serotonin/Norepinephrine Balance and Th1/Th2 Balance,” Current Neuropharmacology, vol. 10, no. 2, pp. 97–123, 2012. View at Publisher · View at Google Scholar
  • Geeta Ramesh, Shemi Benge, Bapi Pahar, and Mario T. Philipp, “A possible role for inflammation in mediating apoptosis of oligodendrocytes as induced by the Lyme disease spirochete Borrelia burgdorferi,” Journal Of Neuroinflammation, vol. 9, 2012. View at Publisher · View at Google Scholar
  • Geon-Ho Jahng, and Songfan Xu, “Local susceptibility causes diffusion alterations in patients with Alzheimer’s disease and mild cognitive impairment,” Brain Imaging and Behavior, vol. 6, no. 3, pp. 426–436, 2012. View at Publisher · View at Google Scholar
  • Naftali Raz, Yiqin Yang, Cheryl L. Dahle, and Susan Land, “Volume of white matter hyperintensities in healthy adults: Contribution of age, vascular risk factors, and inflammation-related genetic variants,” Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol. 1822, no. 3, pp. 361–369, 2012. View at Publisher · View at Google Scholar
  • I. Gerhauser, F. Hansmann, C. Puff, J. Kumnok, D. Schaudien, K. Wewetzer, and W. Baumgärtner, “Theiler's murine encephalomyelitis virus induced phenotype switch of microglia in vitro,” Journal of Neuroimmunology, vol. 252, no. 1-2, pp. 49–55, 2012. View at Publisher · View at Google Scholar
  • Grazyna B. Sadowska, Steven W. Threlkeld, Alexia Flangini, Surendra Sharma, and Barbara S. Stonestreet, “Ontogeny and the effects of in utero brain ischemia on interleukin-1β and interleukin-6 protein expression in ovine cerebral cortex and white matter,” International Journal of Developmental Neuroscience, vol. 30, no. 6, pp. 457–463, 2012. View at Publisher · View at Google Scholar
  • Elzbieta Miller, “Multiple sclerosis,” Advances in Experimental Medicine and Biology, vol. 724, pp. 222–238, 2012. View at Publisher · View at Google Scholar
  • Nadine Correia Santos, Patrício Costa, Dina Ruano, António Macedo, Maria João Soares, José Valente, Ana Telma Pereira, Maria Helena Azevedo, and Joana Almeida Palha, “Revisiting Thyroid Hormones in Schizophrenia,” Journal of Thyroid Research, vol. 2012, pp. 1–15, 2012. View at Publisher · View at Google Scholar
  • James R. Hall, Leigh A. Johnson, Robert C. Barber, Hoa T. Vo, A. Scott Winter, and Sid E. O'Bryant, “Biomarkers of Basic Activities of Daily Living in Alzheimer's Disease,” Journal of Alzheimers Disease, vol. 31, no. 2, pp. 429–437, 2012. View at Publisher · View at Google Scholar
  • A. Carlo Altamura, Massimiliano Buoli, and Sara Pozzoli, “Role of immunological factors in the pathophysiology and diagnosis of bipolar disorder: Comparison with schizophrenia,” Psychiatry and Clinical Neurosciences, 2013. View at Publisher · View at Google Scholar
  • Dearbhaile Dooley, Pia Vidal, and Sven Hendrix, “Immunopharmacological intervention for successful neural stem cell therapy: New perspectives in CNS neurogenesis and repair,” Pharmacology & Therapeutics, 2013. View at Publisher · View at Google Scholar
  • Rodrigo Ribeiro dos Santos, Karen C. Torres, Giselle S. Lima, Carolina M. Fiamoncini, Filipe C. Mapa, Patricia A. Pereira, Vitor B. Rezende, Luiza C. Martins, Maria A. Bicalho, Edgar N. Moraes, Helton J. Reis, Antonio L. Teixeira, and Marco A. Romano-Silva, “Reduced frequency of T lymphocytes expressing CTLA-4 in frontotemporal dementia compared to Alzheimer's disease,” Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2013. View at Publisher · View at Google Scholar
  • Alyaa Mousa, and Moiz Bakhiet, “Role of cytokine signaling during nervous system development,” International Journal of Molecular Sciences, vol. 14, no. 7, pp. 13931–13957, 2013. View at Publisher · View at Google Scholar
  • Marcella Bellani, Nicola Dusi, and Paolo Brambilla, “Can brain imaging address psychosocial functioning and outcome in schizophrenia?,” Improving Mental Health Care, pp. 281–290, 2013. View at Publisher · View at Google Scholar
  • Nagahide Takahashi, and Takeshi Sakurai, “Roles of glial cells in schizophrenia: Possible targets for therapeutic approaches,” Neurobiology of Disease, vol. 53, pp. 49–60, 2013. View at Publisher · View at Google Scholar
  • Tatsuhide Tanaka, Koichi Murakami, Yoshio Bando, and Shigetaka Yoshida, “Minocycline reduces remyelination by suppressing ciliary neurotrophic factor expression after cuprizone-induced demyelination,” Journal of Neurochemistry, 2013. View at Publisher · View at Google Scholar
  • Alexei Verkhratsky, and Arthur Butt2013. View at Publisher · View at Google Scholar
  • Alexei Verkhratsky, and Arthur Butt, “Oligodendrocytes,” Glial Physiology and Pathophysiology, pp. 245–319, 2013. View at Publisher · View at Google Scholar
  • Weijiang Wu, Qing Lan, Hua Lu, Jie Xu, Aihua Zhu, Wenfeng Fang, Feng Ge, and Guozhen Hui, “Human Amnion Mesenchymal Cells Negative Co-stimulatory Molecules PD-L1 Expression and Its Capacity of Modulating Microglial Activation of CNS,” Cell Biochemistry and Biophysics, 2013. View at Publisher · View at Google Scholar
  • Shiwei Wang, and Kaylene M Young, “White matter plasticity in adulthood,” Neuroscience, 2013. View at Publisher · View at Google Scholar
  • E. P. Pasichna, “Use of vitamins for correction of the functional state of cytochrome P450 systems at experimental allergic encephalomyelitis,” The Ukrainian Biochemical Journal, vol. 85, no. 5, pp. 137–148, 2013. View at Publisher · View at Google Scholar
  • Pengxiang She, Piyawan Bunpo, Judy K. Cundiff, Ronald C. Wek, Robert A. Harris, and Tracy G. Anthony, “General Control Nonderepressible 2 (GCN2) Kinase Protects Oligodendrocytes and White Matter during Branched-chain Amino Acid Deficiency in Mice,” Journal of Biological Chemistry, vol. 288, no. 43, pp. 31250–31260, 2013. View at Publisher · View at Google Scholar
  • Tobias Goldmann, and Marco Prinz, “Role of Microglia in CNS Autoimmunity,” Clinical and Developmental Immunology, vol. 2013, pp. 1–8, 2013. View at Publisher · View at Google Scholar
  • Geeta Ramesh, Andrew G. MacLean, and Mario T. Philipp, “Cytokines and Chemokines at the Crossroads of Neuroinflammation, Neurodegeneration, and Neuropathic Pain,” Mediators of Inflammation, vol. 2013, pp. 1–20, 2013. View at Publisher · View at Google Scholar
  • Cong Gao, Li Huang, Youming Long, Jianzheng Zheng, Jie Yang, Shuxiang Pu, and Longchang Xie, “Y-39983, a Selective Rho-Kinase Inhibitor, Attenuates Experimental Autoimmune Encephalomyelitis via Inhibition of Demyelination,” Neuroimmunomodulation, vol. 20, no. 6, pp. 334–340, 2013. View at Publisher · View at Google Scholar
  • Hans-Gert Bernstein, Johann Steiner, Paul C. Guest, Henrik Dobrowolny, and Bernhard Bogerts, “Glial cells as key players in schizophrenia pathology: recent insights and concepts of therapy,” Schizophrenia Research, 2014. View at Publisher · View at Google Scholar
  • Jong Youl Kim, Nuri Kim, and Midori A. Yenari, “Mechanisms and Potential Therapeutic Applications of Microglial Activation after Brain Injury,” CNS Neuroscience & Therapeutics, 2014. View at Publisher · View at Google Scholar
  • Julio Sotelo, “The nervous and the immune systems: conspicuous physiological analogies,” Journal of Comparative Physiology A, 2014. View at Publisher · View at Google Scholar
  • Woo Kyung Kim, Deokhoon Kim, Jun Cui, Ho Hee Jang, Kwang Sei Kim, Hong Jun Lee, and Sung-Min Ahn, “Secretome Analysis of Human Oligodendrocytes Derived from Neural Stem Cells ,” Plos One, vol. 9, no. 1, 2014. View at Publisher · View at Google Scholar
  • Tore Drønen, Kenneth Hugdahl, Renate Grüner, Rune A. Kroken, Else-Marie Løberg, Kristiina Kompus, Silje Skrede, and Erik Johnsen, “A critical review of pro-cognitive drug targets in psychosis: Convergence on myelination and inflammation,” Frontiers in Psychiatry, vol. 5, 2014. View at Publisher · View at Google Scholar
  • Anat Shemer, and Steffen Jung, “Differential roles of resident microglia and infiltrating monocytes in murine CNS autoimmunity,” Seminars in Immunopathology, 2015. View at Publisher · View at Google Scholar
  • Juan C. Leza, Borja García Bueno, Miquel Bioque, Celso Arango, Mara Parellada, Kim Do, Patricio O’Donnell, and Miguel Bernardo, “Inflammation in schizophrenia: a question of balance,” Neuroscience & Biobehavioral Reviews, 2015. View at Publisher · View at Google Scholar
  • Deanna L. Kelly, Kelli M. Sullivan, Joseph P. McEvoy, Robert P. McMahon, Heidi J. Wehring, James M. Gold, Fang Liu, Dale Warfel, Gopal Vyas, Charles M. Richardson, Bernard A. Fischer, William R. Keller, Maju Mathew Koola, Stephanie M. Feldman, Jessica C. Russ, Richard SE Keefe, Jennifer Osing, Leeka Hubzin, Sharon August, Trina M. Walker, and Robert W. Buchanan, “Adjunctive Minocycline in Clozapine-Treated Schizophrenia Patients With Persistent Symptoms,” Journal of Clinical Psychopharmacology, pp. 1, 2015. View at Publisher · View at Google Scholar
  • Grazyna B Sadowska, Xiaodi Chen, Jiyong Zhang, Yow-Pin Lim, Erin E Cummings, Oleksandr Makeyev, Walter G Besio, John Gaitanis, James F Padbury, William A Banks, and Barbara S Stonestreet, “Interleukin-1β transfer across the blood–brain barrier in the ovine fetus,” Journal of Cerebral Blood Flow & Metabolism, 2015. View at Publisher · View at Google Scholar
  • Ki Mo Lee, JiHye Bang, Bu Yeo Kim, In Sun Lee, Jung-Soo Han, Bang Yeon Hwang, and Won Kyung Jeon, “Fructus mume alleviates chronic cerebral hypoperfusion-induced white matter and hippocampal damage via inhibition of inflammation and downregulation of TLR4 and p38 MAPK signaling,” BMC Complementary and Alternative Medicine, vol. 15, no. 1, 2015. View at Publisher · View at Google Scholar
  • Yi-Fang Tu, Chih-Hao Lin, Hsueh-Te Lee, Jing-Jou Yan, Chun-I Sze, Ya-Ping Chou, Chien-Jung Ho, and Chao-Ching Huang, “Elevated cerebrospinal fluid endothelin 1 associated with neurogenic pulmonary edema in children with enterovirus 71 encephalitis,” International Journal of Infectious Diseases, 2015. View at Publisher · View at Google Scholar
  • Danielle E. Harlow, Justin M. Honce, and Augusto A. Miravalle, “Remyelination Therapy in Multiple Sclerosis,” Frontiers in Neurology, vol. 6, 2015. View at Publisher · View at Google Scholar
  • Angélica Roque, Alejandra Ochoa-Zarzosa, and Luz Torner, “Maternal separation activates microglial cells and induces an inflammatory response in the hippocampus of male rat pups, independently of hypothalamic and peripheral cytokine levels,” Brain, Behavior, and Immunity, 2015. View at Publisher · View at Google Scholar
  • Yan-Le Xin, Jie-Zhong Yu, Xin-Wang Yang, Chun-Yun Liu, Yan-Hua Li, Ling Feng, Zhi Chai, Wan-Fang Yang, Qing Wang, Wei-Jia Jiang, Guang-Xian Zhang, Bao-Guo Xiao, and Cun-Gen Ma, “FSD-C10: A more promising novel ROCK inhibitor than Fasudil for treatment of CNS autoimmunity,” Bioscience Reports, vol. 35, 2015. View at Publisher · View at Google Scholar
  • Je-Seong Won, Avtar K. Singh, and Inderjit Singh, “Biochemical, cell biological, pathological, and therapeutic aspects of Krabbe's disease,” Journal of Neuroscience Research, vol. 94, no. 11, pp. 990–1006, 2016. View at Publisher · View at Google Scholar
  • Lianne Hoeijmakers, Yvonne Heinen, Anne-Marie van Dam, Paul J. Lucassen, and Aniko Korosi, “Microglial Priming and Alzheimer’s Disease: A Possible Role for (Early) Immune Challenges and Epigenetics?,” Frontiers in Human Neuroscience, vol. 10, 2016. View at Publisher · View at Google Scholar
  • Evan Z. Goldstein, Jamie S. Church, Zoe C. Hesp, Phillip G. Popovich, and Dana M. McTigue, “A silver lining of neuroinflammation: Beneficial effects on myelination,” Experimental Neurology, 2016. View at Publisher · View at Google Scholar
  • Yong Xu, Weihua Yue, Yin Yao Shugart, Jianmin Yuan, Guoqiang Wang, Harold Z. Wang, Benjamin Lehrman, Fuquan Zhang, and Dai Zhang, “Potential involvement of the interleukin-18 pathway in schizophrenia,” Journal of Psychiatric Research, vol. 74, pp. 10–16, 2016. View at Publisher · View at Google Scholar
  • Verónica Murta, and Carina Ferrari, “Peripheral Inflammation and Demyelinating Diseases,” Glial Cells in Health and Disease of the CNS, vol. 949, pp. 263–285, 2016. View at Publisher · View at Google Scholar
  • L E Laskaris, M A Di Biase, I Everall, G Chana, A Christopoulos, E Skafidas, V L Cropley, and C Pantelis, “Microglial activation and progressive brain changes in schizophrenia,” British Journal of Pharmacology, vol. 173, no. 4, pp. 666–680, 2016. View at Publisher · View at Google Scholar
  • Consuelo Guerri, and María Pascual, “Alcohol and Its Impact on Myelin,” Neuropathology of Drug Addictions and Substance Misuse, pp. 420–432, 2016. View at Publisher · View at Google Scholar
  • Staci D. Bilbo, Carina L. Block, Jessica L. Bolton, Richa Hanamsagar, and Phuong K. Tran, “Beyond infection - Maternal immune activation by environmental factors, microglial development, and relevance for autism spectrum disorders,” Experimental Neurology, 2017. View at Publisher · View at Google Scholar
  • Cg Pascuan, Me Di Rosso, Je Pivoz-Avedikian, Mr Wald, Ma Zorrilla Zubilete, and Am Genaro, “Alteration of neurotrophin and cytokine expression in lymphocytes as novel peripheral markers of spatial memory deficits induced by prenatal stress,” Physiology & Behavior, vol. 173, pp. 144–155, 2017. View at Publisher · View at Google Scholar
  • Elena Mazza, Sara Poletti, Irene Bollettini, Clara Locatelli, Andrea Falini, Cristina Colombo, and Francesco Benedetti, “Body mass index associates with white matter microstructure in bipolar depression,” Bipolar Disorders, 2017. View at Publisher · View at Google Scholar
  • Daniel C. Cole, Youngcheul Chung, Khatuna Gagnidze, Kaitlyn H. Hajdarovic, Violeta Rayon-Estrada, Dewi Harjanto, Benedetta Bigio, Judit Gal-Toth, Teresa A. Milner, Bruce S. McEwen, F. Nina Papavasiliou, and Karen Bulloch, “Loss of APOBEC1 RNA-editing function in microglia exacerbates age-related CNS pathophysiology,” Proceedings of the National Academy of Sciences, pp. 201710493, 2017. View at Publisher · View at Google Scholar
  • Lingli Lu, Xiuping Zhang, Huichun Tong, Wenlong Zhang, Pingyi Xu, and Shaogang Qu, “Central Administration of 5Z-7-Oxozeaenol Protects Experimental Autoimmune Encephalomyelitis Mice by Inhibiting Microglia Activation,” Frontiers in Pharmacology, vol. 8, 2017. View at Publisher · View at Google Scholar
  • Yana O. Mukhamedshina, Elvira R. Akhmetzyanova, Ekaterina V. Martynova, Svetlana F. Khaiboullina, Luisa R. Galieva, and Albert A. Rizvanov, “Systemic and Local Cytokine Profile following Spinal Cord Injury in Rats: A Multiplex Analysis,” Frontiers in Neurology, vol. 8, 2017. View at Publisher · View at Google Scholar
  • Yingying Hu, Zhenmao Li, Jian Xiao, Zhenlang Lin, Zhouguang Wang, Shulin Pan, Hongyu Zhang, Mingchu Fang, Huai Jiang, Hao Zhang, Zhengzheng Gao, and Kebin Xu, “Melatonin protects against blood-brain barrier damage by inhibiting the TLR4/NF-κB signaling pathway after LPS treatment in neonatal rats,” Oncotarget, vol. 8, no. 19, pp. 31638–31654, 2017. View at Publisher · View at Google Scholar
  • Jonathan Repple, Nils Opel, Susanne Meinert, Ronny Redlich, Tim Hahn, Nils R. Winter, Claas Kaehler, Daniel Emden, Ramona Leenings, Dominik Grotegerd, Dario Zaremba, Christian Bürger, Katharina Förster, Katharina Dohm, Verena Enneking, Elisabeth J. Leehr, Joscha Böhnlein, Greta Karliczek, Walter Heindel, Harald Kugel, Jochen Bauer, Volker Arolt, and Udo Dannlowski, “Elevated body-mass index is associated with reduced white matter integrity in two large independent cohorts,” Psychoneuroendocrinology, vol. 91, pp. 179–185, 2018. View at Publisher · View at Google Scholar
  • Mourad Belkhelfa, Narimene Beder, Daya Mouhoub, Manel Amri, Rafa Hayet, Nabila Tighilt, Souad Bakheti, Soraya Laimouche, Djamel Azzouz, Rachid Belhadj, and Chafia Touil-Boukoffa, “The involvement of neuroinflammation and necroptosis in the hippocampus during vascular dementia,” Journal of Neuroimmunology, 2018. View at Publisher · View at Google Scholar
  • Antonietta Santoro, Chiara Carmela Spinelli, Stefania Martucciello, Stefania Lucia Nori, Mario Capunzo, Annibale Alessandro Puca, and Elena Ciaglia, “Innate immunity and cellular senescence: The good and the bad in the developmental and aged brain,” Journal of Leukocyte Biology, 2018. View at Publisher · View at Google Scholar