Directions in Science | Open Access
Chery A. Whipple, Arthur D. Lander, Murray Korc, "Discovery of a Novel Molecule that Regulates Tumor Growth and Metastasis", The Scientific World Journal, vol. 8, Article ID 823287, 4 pages, 2008. https://doi.org/10.1100/tsw.2008.152
Discovery of a Novel Molecule that Regulates Tumor Growth and Metastasis
The heparan sulfate proteoglycan, Glypican-1 (GPC1), significantly impacts the growth of pancreatic cancer cells in vivo and markedly attenuates tumor angiogenesis and metastasis in athymic mice. Interestingly, both cancer cell–derived and host-derived GPC1 play an important role in tumor development and spread. These data suggest that GPC1 may be a valid therapeutic target for pancreatic cancer.