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TheScientificWorldJOURNAL
Volume 8, Pages 752-756
http://dx.doi.org/10.1100/tsw.2008.100
Research Article

Antileishmanial Activity of Aldonamides and N-Acyl-Diamine Derivatives

1Departamento de Parasitologia, Microbiologia e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Juiz de Fora, Cidade Universitária, 36036-900, Juiz de Fora, MG, Brazil
2Departamento de Quíca, Instituto de Ciências Exatas, Universidade Federal de Juiz de Fora, Cidade Universitária, 36036-900, Juiz de Fora, MG, Brazil

Received 8 April 2008; Accepted 14 July 2008

Academic Editor: Frank S. Walsh

Copyright © 2008 Elaine S. Coimbra et al.

Abstract

A number of lipophilic N-acyl-diamines and aldonamides have been synthesized and tested for their in vitro antiproliferative activity against Leishmania amazonensis and L. chagasi. Ribonamides, having one amino group, displayed good to moderate inhibition of parasite growth. The best result was obtained for compounds 10 and 15 with IC50 against L. chagasi below 5 μM.