Antileishmanial Activity of Aldonamides and <i>N</i>-Acyl-Diamine Derivatives

Coimbra, Elaine S.; Almeida, Camila G.; Júnior, Wilson V.; Dos Reis, Roberta C. N.; De Almeida, Ana C. F.; Forezi, Luana S. M.; De Almeida, Mauro V.; Le Hyaric, Mireille

doi:https://doi.org/10.1100/tsw.2008.100

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Research Article | Open Access

Volume 8 | Article ID 857079 | https://doi.org/10.1100/tsw.2008.100

Antileishmanial Activity of Aldonamides and N-Acyl-Diamine Derivatives

Elaine S. Coimbra,¹Camila G. Almeida,²Wilson V. Júnior,¹Roberta C. N. Dos Reis,²Ana C. F. De Almeida,¹Luana S. M. Forezi,²Mauro V. De Almeida,²and Mireille Le Hyaric²

Academic Editor: Frank S. Walsh

Received08 Apr 2008

Accepted14 Jul 2008

Abstract

A number of lipophilic N-acyl-diamines and aldonamides have been synthesized and tested for their in vitro antiproliferative activity against Leishmania amazonensis and L. chagasi. Ribonamides, having one amino group, displayed good to moderate inhibition of parasite growth. The best result was obtained for compounds 10 and 15 with IC₅₀ against L. chagasi below 5 μM.

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