Antileishmanial Activity of Aldonamides and N-Acyl-Diamine Derivatives
Elaine S. Coimbra,1Camila G. Almeida,2Wilson V. Júnior,1Roberta C. N. Dos Reis,2Ana C. F. De Almeida,1Luana S. M. Forezi,2Mauro V. De Almeida,2and Mireille Le Hyaric2
Academic Editor: Frank S. Walsh
Received08 Apr 2008
Accepted14 Jul 2008
Abstract
A number of lipophilic N-acyl-diamines and aldonamides have been synthesized and tested for their in vitro antiproliferative activity against Leishmania amazonensis and L. chagasi. Ribonamides, having one amino group, displayed good to moderate inhibition of parasite growth. The best result was obtained for compounds 10 and 15 with IC50 against L. chagasi below 5 μM.