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Volume 8, Pages 303-312
Research Article

Prognostic Significance of Lymphovascular Invasion in Clinically Localized Prostate Cancer after Radical Prostatectomy

1Department of Pathology, Hacettepe University, School of Medicine, Ankara, 06100, Turkey
2Department of Urology, Hacettepe University, School of Medicine, Ankara, 06100, Turkey
3Department of Biostatistics, Hacettepe University, School of Medicine, Ankara, 06100, Turkey

Received 20 September 2007; Revised 26 February 2008; Accepted 3 March 2008

Academic Editor: Peter E. Clark

Copyright © 2008 Dilek Ertoy Baydar et al.


Whether lymphovascular invasion (LVI) is an independent prognostic factor in prostate cancer is still controversial. We retrospectively investigated its predictive role in disease progression following radical prostatectomy. The histological sections of radical prostatectomies from 71 clinically localized, prostatic adenocarcinoma patients were reviewed for LVI. Pre- and postoperative follow-up data were collected. LVI was identified in 15.5% of cases. Univariate analysis showed a significant association between LVI and advanced pathological stage, higher Gleason score, positive surgical margins, extraprostatic extension, seminal vesicle invasion, and lymph node metastasis (each p < 0.05). Multivariate analyses pointed to vascular involvement as a strong and independent predictor for PSA failure (p = 0.023), and reduced biochemical progression-free survival (p = 0.019). LVI in radical prostatectomy is an adverse prognostic finding that must be recorded in the pathology report.