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TheScientificWorldJOURNAL
Volume 8 (2008), Pages 270-274
http://dx.doi.org/10.1100/tsw.2008.48
Mini-Review

Heat Shock Proteins and Neurodegenerative Disorders

Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, 4 Medical Drive, Block MD10, Singapore 117597, Singapore

Received 29 October 2007; Accepted 21 February 2008

Copyright © 2008 Eliza Ting-Li Soo et al.

Abstract

Heat shock proteins (HSPs) are evolutionarily conserved molecules and play important roles in fundamental cellular processes. They serve as molecular chaperones and hence provide a protective function in ensuring cell survival and repair of cellular damage after a stressful stimulus. This paper summarizes the current knowledge about the different roles of HSPs in aging and disease, focusing on the neurodegenerative disorders of Alzheimer's disease, Parkinson's disease, Huntington's disease, and prion disease.