Sexual DysfunctionView this Special Issue
Mini-Review Article | Open Access
Arnold Melman, Kelvin P. Davies, "Gene Therapy in the Management of Erectile Dysfunction (ED): Past, Present, and Future", The Scientific World Journal, vol. 9, Article ID 137949, 9 pages, 2009. https://doi.org/10.1100/tsw.2009.102
Gene Therapy in the Management of Erectile Dysfunction (ED): Past, Present, and Future
In the past, many researchers considered viral vectors to be the most promising candidates to transfer genetic material into the corpora for the treatment of erectile dysfunction. However, at present, no viral vectors have progressed to human trials. In contrast, the use of naked gene therapy, a plasmid expressing the human Maxi-K potassium channel, is the only gene therapy treatment to be evaluated in clinical phase I trials to date. The success of these studies, proving the safety of this treatment, has paved the way for the development of future gene transfer techniques based on similar transfer methods, as well as novel treatment vectors, such as stem cell transfer.