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TheScientificWorldJOURNAL
Volume 9 (2009), Pages 404-419
http://dx.doi.org/10.1100/tsw.2009.52
Review Article

Biophysical and Structural Studies on the Capsid Protein of the Human Immunodeficiency Virus Type 1: A New Drug Target?

1Instituto de Biología Molecular y Celular, Universidad Miguel Hernáez, 03202 Elche (Alicante), Spain
2Biocomputation and Complex Systems Physics Institute, 50009 Zaragoza, Spain

Received 12 December 2008; Revised 13 May 2009; Accepted 18 May 2009

Academic Editor: Nuno C. Santos

Copyright © 2009 Jose L Neira.

Citations to this Article [8 citations]

The following is the list of published articles that have cited the current article.

  • José L. Neira, “The capsid protein of human immunodeficiency virus: designing inhibitors of capsid assembly,” FEBS Journal, vol. 276, no. 21, pp. 6110–6117, 2009. View at Publisher · View at Google Scholar
  • Rosa Domenech, Olga Abian, Rebeca Bocanegra, Juan Correa, Ana Sousa-Herves, Ricardo Riguera, Mauricio G. Mateu, Eduardo Fernandez-Megia, Adrian Velazquez-Campoy, and Jose L. Neira, “Dendrimers as Potential Inhibitors of the Dimerization of the Capsid Protein of HIV-1,” Biomacromolecules, vol. 11, no. 8, pp. 2069–2078, 2010. View at Publisher · View at Google Scholar
  • Nuno C. Santos, “In and Out - Biochemical and Biophysical Mechanisms of Viral Fusion and Assembly,” Thescientificworldjournal, vol. 10, pp. 419–421, 2010. View at Publisher · View at Google Scholar
  • Rebeca Bocanegra, María Nevot, Rosa Doménech, Inmaculada López, Olga Abián, Alicia Rodríguez-Huete, Claudio N. Cavasotto, Adrián Velázquez-Campoy, Javier Gómez, Miguel Ángel Martínez, José Luis Neira, and Mauricio G. Mateu, “Rationally designed interfacial peptides are efficient in vitro inhibitors of HIV-1 capsid assembly with antiviral activity,” PLoS ONE, vol. 6, no. 9, 2011. View at Publisher · View at Google Scholar
  • Rosa Domenech, Rebeca Bocanegra, Rosario Gonzalez-Muniz, Javier Gomez, Mauricio G. Mateu, and Jose L. Neira, “Larger Helical Populations in Peptides Derived from the Dimerization Helix of the Capsid Protein of HIV-1 Results in Peptide Binding toward Regions Other than the "Hotspot" Interface,” Biomacromolecules, vol. 12, no. 9, pp. 3252–3264, 2011. View at Publisher · View at Google Scholar
  • Rosa Doménech, Rebeca Bocanegra, Adrián Velázquez-Campoy, and José L. Neira, “The isolated major homology region of the HIV capsid protein is mainly unfolded in solution and binds to the intact protein,” Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, vol. 1814, no. 10, pp. 1269–1278, 2011. View at Publisher · View at Google Scholar
  • Rebeca Bocanegra, Alicia Rodríguez-Huete, Miguel Ángel Fuertes, Marta del Álamo, and Mauricio G. Mateu, “Molecular recognition in the human immunodeficiency virus capsid and antiviral design,” Virus Research, vol. 169, no. 2, pp. 388–410, 2012. View at Publisher · View at Google Scholar
  • Rosa Doménech, and José L. Neira, “The HIV-1 capsid protein as a drug target: Recent advances and future prospects,” Current Protein and Peptide Science, vol. 14, no. 8, pp. 658–668, 2013. View at Publisher · View at Google Scholar