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Volume 9, Pages 564-574
Mini-Review Article

Hypercholesterolemia and 3-Hydroxy 3-Methylglutaryl Coenzyme A Reductase Regulation during Ageing

Department of Biology, University of Roma Tre, Roma, Italy

Received 3 March 2009; Revised 3 June 2009; Accepted 17 June 2009

Academic Editor: Rudy Tanzi

Copyright © 2009 Laura Trapani and Valentina Pallottini.


We present here a brief description of the path that cholesterol covers from its intestinal absorption to its effect exerted on some enzyme regulation. Some mechanisms underlying hypercholesterolemia onset and, in particular, the role and the regulation of 3-hydroxy 3-methylglutaryl Coenzyme A reductase (HMGR) during adult life and during aging, have been described. In addition some pharmacological interventions to control proper HMGR regulation and, in turn, cholesterol homeostasis maintenance will be introduced.