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Volume 9 (2009), Pages 366-372
Mini-Review Article

Aging Brain: Prevention of Oxidative Stress by Vitamin E and Exercise

Laboratory of Gerontology, Department of Zoology, Bangalore University, Bangalore 560 056, India

Received 25 March 2009; Revised 13 May 2009; Accepted 14 May 2009

Academic Editor: Rudy Tanzi

Copyright © 2009 Sambe Asha Devi.


With aging, the brain undergoes neuronal loss in many areas. Although the loss of cells in the cerebral cortex, in particular the frontal cortex, has been recognized with aging, the influence of synaptic losses has a larger impact on cognitive decline. Much of the recent research on animals, as well as humans, has been aimed at slowing the cognitive decline through enrichment, and it has been found that the key factors are antioxidants and exercise. Several reports support the concept that regular supplementation of vitamin E and physical activity from as early as middle age can slow the cognitive decline observed during the later years. A few studies have also suggested that exercise is analogous to acetylcholine esterase inhibitors that are also used extensively to treat cognitive impairment and dementia in Alzheimer's disease. In addition, reports also support that vitamin E and exercise may act synergistically to overcome free radical injury and oxidative stress in the aging brain.