The Scientific World Journal

The Scientific World Journal / 2009 / Article
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Hemaglobinopathies

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Review Article | Open Access

Volume 9 |Article ID 529605 | https://doi.org/10.1100/tsw.2009.69

Sylvia Titi Singer, "Variable Clinical Phenotypes of α-Thalassemia Syndromes", The Scientific World Journal, vol. 9, Article ID 529605, 11 pages, 2009. https://doi.org/10.1100/tsw.2009.69

Variable Clinical Phenotypes of α-Thalassemia Syndromes

Academic Editor: Susan Perrine
Received31 Oct 2008
Revised01 Jun 2009
Accepted05 Jun 2009

Abstract

Genetic mutations of the α genes are common worldwide. In Asia and particularly Southeast Asia, they can result in clinically significant types of α-thalassemia, namely hemoglobin (Hb) H disease and Hb Bart's hydrops fetalis. The latter is generally a fatal intrauterine condition, while Hb H disease results in clinical complications that are frequently overlooked. The high prevalence of the carrier state and the burden of these diseases (and other α-thalassemia variants) call for more attention for improved screening methods and better care.


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