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TheScientificWorldJOURNAL
Volume 10 (2010), Pages 2288-2300
http://dx.doi.org/10.1100/tsw.2010.215
Research Article

Treatment with Nasal Neuro-EPO Improves the Neurological, Cognitive, and Histological State in a Gerbil Model of Focal Ischemia

1Histology Department Preclinical and Basic Science Institute, Havana, Cuba
2National Center for Laboratory Animal Breeding, Havana, Cuba
3Center of Research and Development of Medicaments (CIDEM), Havana, Cuba
4Institute of Neurology and Neurosurgery (INN), Havana, Cuba
5Neuroscience Group of the National Center for Laboratory Animal Breeding (CENPALAB), Havana, Cuba

Received 12 December 2009; Revised 16 October 2010; Accepted 19 October 2010

Academic Editor: Dirk Hermann

Copyright © 2010 Yamila Rodríguez Cruz et al.

Citations to this Article [15 citations]

The following is the list of published articles that have cited the current article.

  • Dirk M. Hermann, “Nonhematopoietic Variants of Erythropoietin in Ischemic Stroke: Need for Step-Wise Proof-of-Concept Studies,” Thescientificworldjournal, vol. 10, pp. 2285–2287, 2010. View at Publisher · View at Google Scholar
  • Giselle Penton-Rol, Javier Marin-Prida, Gilberto Pardo-Andreu, Gregorio Martinez-Sanchez, Emilio Felino Acosta-Medina, Alain Valdivia-Acosta, Nielsen Lagumersindez-Denis, Efrain Rodriguez-Jimenez, Alexey Llopiz-Arzuaga, Pedro Antonio Lopez-Saura, Gerardo Guillen-Nieto, and Eduardo Penton-Arias, “C-Phycocyanin is neuroprotective against global cerebral ischemia/reperfusion injury in gerbils,” Brain Research Bulletin, vol. 86, no. 1-2, pp. 42–52, 2011. View at Publisher · View at Google Scholar
  • Mofidi, Bader, and Pavlica, “The use of erythropoietin and its derivatives to treat Spinal Cord injury,” Mini-Reviews in Medicinal Chemistry, vol. 11, no. 9, pp. 763–770, 2011. View at Publisher · View at Google Scholar
  • David J. Eve, Cesar V. Borlongan, and Paul R. Sanberg, “A Showcase of Bench-to-Bedside Regenerative Medicine at the 2010 ASNTR,” The Scientific World JOURNAL, vol. 11, pp. 1842–1864, 2011. View at Publisher · View at Google Scholar
  • Heiko Sorg, Yves Harder, Christian Krueger, Kerstin Reimers, and Peter M. Vogt, “The Nonhematopoietic Effects of Erythropoietin in Skin Regeneration and Repair: From Basic Research to Clinical Use,” Medicinal Research Reviews, vol. 33, no. 3, pp. 637–664, 2012. View at Publisher · View at Google Scholar
  • Iliana Sosa Teste, Yuneidys Mengana Tamos, Yamila Rodríguez Cruz, Adriana Muñoz Cernada, Janette Cruz Rodríguez, Nelvis Subirós Martínez, Rosa Maria Coro Antich, Alina González-Quevedo, and Julio Cesar García Rodríguez, “Dose Effect Evaluation and Therapeutic Window of the Neuro-EPO Nasal Application for the Treatment of the Focal Ischemia Model in the Mongolian Gerbil,” The Scientific World Journal, vol. 2012, pp. 1–12, 2012. View at Publisher · View at Google Scholar
  • Hongbo Wang, Yuxiang Liz, Ning Jiang, Xiaoping Chen, Yi Zhang, Kuai Zhang, Tengfei Wang, Yinju Hao, Lin Ma, Chengjun Zhao, Yanrong Wang, Tao Sun, and Jiandiang Yu, “Protective effect of oxysophoridine on cerebral ischemia/reperfusion injury in mice,” Neural Regeneration Research, vol. 8, no. 15, pp. 1349–1359, 2013. View at Publisher · View at Google Scholar
  • Tangui Maurice, Muhammad-Hariri Mustafa, Catherine Desrumaux, Emeline Keller, Gaelle Naert, Maria de la C. Garcia-Barcelo, Yamila Rodriguez Cruz, and Julio Cesar Garcia Rodriguez, “Intranasal formulation of erythropoietin (EPO) showed potent protective activity against amyloid toxicity in the A beta(25-35) non-transgenic mouse model of Alzheimer's disease,” Journal of Psychopharmacology, vol. 27, no. 11, pp. 1044–1057, 2013. View at Publisher · View at Google Scholar
  • Amirah E-E Aly, and Barbara L Waszczak, “Intranasal gene delivery for treating Parkinson’s disease: overcoming the blood–brain barrier,” Expert Opinion on Drug Delivery, vol. 12, no. 12, pp. 1923–1941, 2015. View at Publisher · View at Google Scholar
  • Yong-Sheng Wang, Yu-Xiang Li, Peng Zhao, Hong-Bo Wang, Ru Zhou, Yin-Ju Hao, Jie Wang, Shu-Jing Wang, Juan Du, Lin Ma, Tao Sun, and Jian-Qiang Yu, “Anti-inflammation Effects of Oxysophoridine on Cerebral Ischemia–Reperfusion Injury in Mice,” Inflammation, 2015. View at Publisher · View at Google Scholar
  • Giuseppe Pignataro, Barbara Ziaco, Anna Tortiglione, Rosaria Gala, Ornella Cuomo, Antonio Vinciguerra, Dominica Lapi, Teresa Mastantuono, serenella anzilotti, Luca Domenico D'Andrea, Carlo Pedone, Gianfranco Di Renzo, Lucio Annunziato, and Mauro Cataldi, “Neuroprotective Effect Of The Vegf-Mimetic Peptide Qk In Experimental Brain Ischemia Induced In Rat By Middle Cerebral Artery Occlusion,” ACS Chemical Neuroscience, pp. 150714085708007, 2015. View at Publisher · View at Google Scholar
  • Yamila Rodríguez Cruz, Manon Strehaiano, Teresita Rodríguez Obaya, Julío César García Rodríguez, and Tangui Maurice, “An Intranasal Formulation of Erythropoietin (Neuro-EPO) Prevents Memory Deficits and Amyloid Toxicity in the APPSwe Transgenic Mouse Model of Alzheimer’s Disease,” Journal of Alzheimer's Disease, pp. 1–18, 2016. View at Publisher · View at Google Scholar
  • Seung-Jun Yoo, Bongki Cho, Deokho Lee, Gowoon Son, Yeong-Bae Lee, Hyung Soo Han, Eunjoo Kim, Chanil Moon, and Cheil Moon, “The erythropoietin-derived peptide MK-X and erythropoietin have neuroprotective effects against ischemic brain damage,” Cell Death and Disease, vol. 8, no. 8, pp. e3003, 2017. View at Publisher · View at Google Scholar
  • Orestes Santos-Morales, Alina Díaz-Machado, Daise Jiménez-Rodríguez, Yaisel Pomares-Iturralde, Tatiana Festary-Casanovas, Carlos A. González-Delgado, Sonia Pérez-Rodríguez, Eulalia Alfonso-Muñoz, Carmen Viada-González, Patricia Piedra-Sierra, Idrian García-García, Daniel Amaro-González, Julio César García-Rodríguez, Iliana Sosa-Testé, Alicia Lagarto-Parra, Laura Barrero-Viera, Marlene David-Baldo, Maura Tamayo-Rodríguez, Ivonne Rivero-Vázquez, Gricel González-Gamiz, Alis Martín-Trujillo, Yasmila Rodríguez-Fernández, Ana Alfa Ledo-de la Luz, Maylén Álvarez-Delgado, Ivón Howland-Álvarez, and Yolanda Cruz-Gómez, “Nasal administration of the neuroprotective candidate NeuroEPO to healthy volunteers: a randomized, parallel, open-label safety study,” BMC Neurology, vol. 17, no. 1, 2017. View at Publisher · View at Google Scholar
  • Garzón Fernando, Rodríguez Yamila, García Cesar, and Rama Ramón, “Neuroprotective Effects of neuroEPO Using an In Vitro Model of Stroke,” Behavioral Sciences, vol. 8, no. 2, pp. 26, 2018. View at Publisher · View at Google Scholar