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TheScientificWorldJOURNAL
Volume 10 (2010), Pages 2254-2264
http://dx.doi.org/10.1100/tsw.2010.219
Mini-Review Article

Ca2+ Signaling in B Cells

Department of Medicine, University of Colorado Denver School of Medicine, USA

Received 4 September 2010; Revised 20 October 2010; Accepted 31 October 2010

Academic Editor: Marco A. Cassatella

Copyright © 2010 Taras¬†Lyubchenko.

Abstract

An increase in intracellular Ca2+ concentration is one of the major initial steps in B-cell activation that occurs within minutes after antigen receptor (BCR) engagement. In recent years, significant advances have been made in characterizing molecular mechanisms of Ca2+ signaling in lymphocytes, although the majority of work was done on T cells. This mini-review discusses several underexplored areas of Ca2+ signaling in B cells: (1) Ca2+ signaling in immune synapse and multifaceted Ca2+ responses within a single cell, (2) source of Ca2+ involved in Ca2+-dependent protein phosphorylation events and the role of store-operated influx, (3) role of BCR coreceptors in Ca2+ signaling, and (4) Ca2+ signaling and maintenance of B-cell tolerance and clinical significance of Ca2+ signaling alterations.