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Volume 10 (2010), Pages 1416-1423
Peer-Reviewed Protocol

Cerebral Hemodynamic Changes during the Trigeminocardiac Reflex: Description of a New Animal Model Protocol

1Neurosurgical Department, University of Paris, France
2Neurosurgical Department, University of Erlangen, Germany
3Neurosurgical Department, University of Münster, Germany
4Biochemistry Department, Irkutsk State Medical University, Irkutsk, Russia

Received 4 February 2010; Revised 11 April 2010; Accepted 12 June 2010

Academic Editor: Peter Little

Copyright © 2010 N. Sandu et al.


The trigeminocardiac reflex (TCR) is a well-known brainstem reflex, first described in skull base and neurosurgery by the senior author in 1999, leading to reflex apnea, bradycardia, and changes of mean arterial pressure. There seem to be differences between peripheral and central stimulation of the TCR, and there is a lack of clear data about the cerebral hemodynamic changes during the TCR. However, the research of this reflex principally focused on clinical cases for peripheral and central stimulation during the last years, and on rabbits for peripheral stimulation several decades ago, so there was a need for an animal model that allows us to use the current state-of-the-art imaging methods. The new animal model protocol as introduced by the authors gives, for the first time, deep insights into the cerebral hemodynamic changes during the TCR and gives substantial evidence whether the TCR represents an oxygen-conserving reflex or not.