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Volume 10, Pages 457-461
Mini-Review Article

Hepatocyte Growth Factor in Synaptic Plasticity and Alzheimer's Disease

National Brain Research Centre, Manesar, Haryana-122050, India

Received 13 October 2009; Revised 27 February 2010; Accepted 1 March 2010

Academic Editor: Rudy Tanzi

Copyright © 2010 Shiv K. Sharma.


The hepatocyte growth factor (HGF) was initially identified as a protein that promoted growth of hepatocytes. It regulates proliferation and survival of different types of cells. HGF signaling, which is initiated by its binding to a receptor tyrosine kinase, plays critical roles during development. HGF and its receptor are also present in brain cells. This review describes the role of HGF in hippocampal neurons, synaptic plasticity, and the memory impairment condition, Alzheimer's disease.