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TheScientificWorldJOURNAL
Volume 10 (2010), Pages 997-1000
http://dx.doi.org/10.1100/tsw.2010.95
Directions in Science

Artificial Organelles: Digital Microfluidic Platform for Proteoglycan and Glycoprotein Biosynthesis

1Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Center for Biotechnology and Interdisciplinary Studies, Troy, NY, USA
2Department of Biology, Rensselaer Polytechnic Institute, Center for Biotechnology and Interdisciplinary Studies, Troy, NY, USA
3Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Center for Biotechnology and Interdisciplinary Studies, Troy, NY, USA

Received 14 January 2010; Revised 27 April 2010; Accepted 29 April 2010

Academic Editor: Martin Goette

Copyright © 2010 Jeffrey G. Martin et al.

Abstract

The development of artificial organelles is a new, fast-growing field in which a variety of techniques have been employed. This article gives a brief overview of the history of artificial organelles, and describes the development of an artificial endoplasmic reticulum and Golgi organelle on a digital microfluidic platform. This device should be useful in high-throughput combinatorial proteoglycan/glycoprotein synthesis, providing critical information about the control of biosynthetic pathways for these important signaling molecules.