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Volume 10, Pages 796-798
Case Study

Reversible Renal Insufficiency Secondary to Extrinsic Splenic Compression of the Kidney in a Patient with Chronic Lymphocytic Leukemia

Division of Urology, Medical College of Georgia, Augusta, GA, USA

Received 1 February 2010; Revised 1 April 2010; Accepted 6 April 2010

Academic Editor: Daniel Batlle

Copyright © 2010 Miriam Hadj-Moussa and James A. Brown.


While increased renal venous and direct renal parenchymal pressure may cause renal insufficiency, there are no prior reports of hypersplenism secondary to chronic lymphocytic leukemia (CLL) doing so. This first report of massive splenomegaly leading to marked compression of the left kidney associated with renal insufficiency that resolved after splenectomy illustrates that profound extrinsic renal compression from splenomegaly may significantly compromise left renal function and splenectomy should be considered in this situation.