Pancreatic CancerView this Special Issue
Review Article | Open Access
Carla Cano, Yoshiharu Motoo, Juan L. Iovanna, "Epithelial-to-Mesenchymal Transition in Pancreatic Adenocarcinoma", The Scientific World Journal, vol. 10, Article ID 658514, 11 pages, 2010. https://doi.org/10.1100/tsw.2010.183
Epithelial-to-Mesenchymal Transition in Pancreatic Adenocarcinoma
Epithelial to mesenchymal transition (EMT) is a physiologic process that allows morphological and genetic changes of carcinoma cells from an epithelial to a mesenchymal phenotype, which is the basis of the high metastatic potential of pancreatic cancer cells. EMT is triggered by various tumor microenvironmental factors, including cytokines, growth factors, and chemotherapeutic agents. This review summarizes the state-of-the-art knowledge on the molecular mechanisms that support pancreatic cancer EMT and the evidences that support its involvement in invasiveness/aggressiveness, and the drug resistance of pancreatic cancer cells.