The Scientific World Journal

The Scientific World Journal / 2010 / Article
Special Issue

Pancreatic Cancer

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Review Article | Open Access

Volume 10 |Article ID 658514 |

Carla Cano, Yoshiharu Motoo, Juan L. Iovanna, "Epithelial-to-Mesenchymal Transition in Pancreatic Adenocarcinoma", The Scientific World Journal, vol. 10, Article ID 658514, 11 pages, 2010.

Epithelial-to-Mesenchymal Transition in Pancreatic Adenocarcinoma

Academic Editor: Juan Iovanna
Received21 Jul 2010
Revised07 Sep 2010
Accepted08 Sep 2010


Epithelial to mesenchymal transition (EMT) is a physiologic process that allows morphological and genetic changes of carcinoma cells from an epithelial to a mesenchymal phenotype, which is the basis of the high metastatic potential of pancreatic cancer cells. EMT is triggered by various tumor microenvironmental factors, including cytokines, growth factors, and chemotherapeutic agents. This review summarizes the state-of-the-art knowledge on the molecular mechanisms that support pancreatic cancer EMT and the evidences that support its involvement in invasiveness/aggressiveness, and the drug resistance of pancreatic cancer cells.

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