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Volume 10 (2010), Pages 1958-1966
Review Article

Stress Proteins and Pancreatic Cancer Metastasis

INSERM U.624, Stress Cellulaire, Parc Scientifique et Technologique de Luminy, Marseille, France

Received 29 March 2010; Revised 28 May 2010; Accepted 1 June 2010

Academic Editor: Juan Iovanna & Jose Neira

Copyright © 2010 Carla E. Cano and Juan L. Iovanna.


Tumor metastasis is challenged by its resistance to microenvironmental stress infringed during escape from the primary tumor and the colonization of a foreign secondary tissue. Because of its great metastatic potential and its strong resistance to anticancer drugs, pancreatic cancer is regarded as a paradigm of the adaptation of cancer cells to microenvironmental stress. Thus, to understand how pancreatic cancer cells adapt to the different endogenous and therapy-related stresses is crucial for understanding their etiology and for the development of new efficient anticancer strategies. This review summarizes the multiple functions accomplished by one major factor of pancreatic cancer cell stress response, the stress protein p8.