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TheScientificWorldJOURNAL
Volume 10 (2010), Pages 944-953
http://dx.doi.org/10.1100/tsw.2010.85
Review Article

An Emerging Role for IQGAP1 in Regulating Protein Traffic

Department of Molecular Pharmacology, Physiology and Biotechnology, Division of Biology and Medicine, Alpert School of Medicine, Brown University, Providence, RI, USA

Received 4 February 2010; Revised 14 April 2010; Accepted 15 April 2010

Academic Editor: Norbert Perrimon

Copyright © 2010 Mahasin Osman.

Citations to this Article [19 citations]

The following is the list of published articles that have cited the current article.

  • Yan Wu, Yong-Chang Chen, Jian-Rong Sang, and Wen-Rong Xu, “RhoC protein stimulates migration of gastric cancer cells through interaction with scaffold protein IQGAP1,” Molecular Medicine Reports, vol. 4, no. 4, pp. 697–703, 2011. View at Publisher · View at Google Scholar
  • Yanyun Xie, Judy Yan, Jean-Claude Cutz, Adrian P. Rybak, Lizhi He, Fengxiang Wei, Anil Kapoor, Valentina A. Schmidt, Lijian Tao, and Damu Tang, “IQGAP2, A candidate tumour suppressor of prostate tumorigenesis,” Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol. 1822, no. 6, pp. 875–884, 2012. View at Publisher · View at Google Scholar
  • Yemsrach K. Tekletsadik, Robert Sonn, and Mahasin A. Osman, “A conserved role of IQGAP1 in regulating TOR complex 1,” Journal of Cell Science, vol. 125, no. 8, pp. 2041–2052, 2012. View at Publisher · View at Google Scholar
  • Subramaniam Malarkannan, Aradhana Awasthi, Kamalakannan Rajasekaran, Pawan Kumar, Kristina M. Schuldt, Allison Bartoszek, Niranjan Manoharan, Nicholas K. Goldner, Colleen M. Umhoefer, and Monica S. Thakar, “IQGAP1: A Regulator of Intracellular Spacetime Relativity,” Journal of Immunology, vol. 188, no. 5, pp. 2057–2063, 2012. View at Publisher · View at Google Scholar
  • Mahasin A. Osman, Fazlul H. Sarkar, and Enrique Rodriguez-Boulan, “A molecular rheostat at the interface of cancer and diabetes,” Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, vol. 1836, no. 1, pp. 166–176, 2013. View at Publisher · View at Google Scholar
  • Suyong Choi, Narendra Thapa, Andrew C Hedman, Zhigang Li, David B Sacks, and Richard A Anderson, “IQGAP1 is a novel phosphatidylinositol 4,5 bisphosphate effector in regulation of directional cell migration,” The EMBO Journal, 2013. View at Publisher · View at Google Scholar
  • Mahasin A. Osman, George S. Bloom, and Emmanuel A. Tagoe, “ Helicobacter pylori -induced alteration of epithelial cell signaling and polarity: A possible mechanism of gastric carcinoma etiology and disparity ,” Cytoskeleton, 2013. View at Publisher · View at Google Scholar
  • Xiao-Xia Wang, Xiao-Zhong Li, Li-Qin Zhai, Zhi-Rong Liu, Xian-Jiu Chen, and Yi Pei, “Overexpression of IQGAP1 in human pancreatic cancer,” Hepatobiliary & Pancreatic Diseases International, vol. 12, no. 5, pp. 540–545, 2013. View at Publisher · View at Google Scholar
  • Jianhong Lu, Yuliang Liu, Ziying Han, Yonggang Qu, Gordon Ruthel, Ronald N. Harty, Rakesh Jambusaria, and Bruce D. Freedman, “Host IQGAP1 and Ebola Virus VP40 Interactions Facilitate Virus-Like Particle Egress,” Journal Of Virology, vol. 87, no. 13, pp. 7777–7780, 2013. View at Publisher · View at Google Scholar
  • Xiao-Xia Wang, Kang Wang, Xiao-Zhong Li, Li-Qin Zhai, Chong-Xiao Qu, Yan Zhao, Zhi-Rong Liu, Hui-Zhen Wang, Qi-Jun An, Li-Wei Jing, and Xu-Hong Wang, “Targeted Knockdown of IQGAP1 Inhibits the Progression of Esophageal Squamous Cell Carcinoma In Vitro and In Vivo,” Plos One, vol. 9, no. 5, 2014. View at Publisher · View at Google Scholar
  • Inmaculada Bañón-Rodríguez, Manuel Gálvez-Santisteban, Silvia Vergarajauregui, Minerva Bosch, Arantxa Borreguero-Pascual, and Fernando Martín-Belmonte, “EGFR controls IQGAP basolateral membrane localization and mitotic spindle orientation during epithelial morphogenesis,” The EMBO Journal, vol. 33, no. 2, pp. 129–145, 2014. View at Publisher · View at Google Scholar
  • Andrew C. Hedman, Jessica M. Smith, and David B. Sacks, “The biology of IQGAP proteins: Beyond the cytoskeleton,” EMBO Reports, vol. 16, no. 4, pp. 427–446, 2015. View at Publisher · View at Google Scholar
  • Barbara E. Tanos, Andres E. Perez Bay, Susana Salvarezza, Igor Vivanco, Ingo Mellinghoff, Mahasin Osman, David B. Sacks, and Enrique Rodriguez-Boulan, “IQGAP1 controls tight junction formation through differential regulation of claudin recruitment,” Journal Of Cell Science, vol. 128, no. 5, pp. 853–862, 2015. View at Publisher · View at Google Scholar
  • Jessica M. Smith, Andrew C. Hedman, and David B. Sacks, “IQGAPs choreograph cellular signaling from the membrane to the nucleus,” Trends in Cell Biology, 2015. View at Publisher · View at Google Scholar
  • Takashi Watanabe, Shujie Wang, and Kozo Kaibuchi, “IQGAPs as Key Regulators of Actin-cytoskeleton Dynamics,” Cell Structure and Function, vol. 40, no. 2, pp. 69–77, 2015. View at Publisher · View at Google Scholar
  • Barbara E. Tanos, Charles Yeaman, and Enrique Rodriguez-Boulan, “An emerging role for IQGAP1 in tight junction control,” Small GTPases, pp. 1–9, 2016. View at Publisher · View at Google Scholar
  • Meenu R. Rajan, Åsa Jufvas, Cecilia Jönsson, Peter Strålfors, and Maria V. Turkina, “Scaffolding protein IQGAP1: An insulin-dependent link between caveolae and the cytoskeleton in primary human adipocytes?,” Biochemical Journal, vol. 473, no. 19, pp. 3177–3188, 2016. View at Publisher · View at Google Scholar
  • Yang Liu, Tao Song, and Dongyue Su, “Knockdown of IQGAP1 inhibits proliferation and epithelial–mesenchymal transition by Wnt/β-catenin pathway in thyroid cancer,” OncoTargets and Therapy, vol. 10, pp. 1549–1559, 2017. View at Publisher · View at Google Scholar
  • Ziwei Liang, Yanfang Yang, Yu He, Pengbo Yang, Xixi Wang, Gu He, Peng Zhang, Hongxia Zhu, Ningzhi Xu, Xia Zhao, and Shufang Liang, “SUMOylation of IQGAP1 promotes the development of colorectal cancer,” Cancer Letters, 2017. View at Publisher · View at Google Scholar