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TheScientificWorldJOURNAL
Volume 10, Pages 1370-1385
http://dx.doi.org/10.1100/tsw.2010.120
Review Article

Molecular Circuits of Resolution in Renal Disease

UCD Diabetes Research Centre, UCD Conway Institute, School of Medicine and Medical Sciences, University College Dublin, Ireland

Received 19 March 2010; Revised 18 May 2010; Accepted 20 May 2010

Academic Editor: Joan Clària

Copyright © 2010 Emma Börgeson and Catherine Godson.

Abstract

Inflammation is a common feature of renal pathology. Lipid mediators, such as lipoxins, resolvins, and protectins, can actively promote the resolution of inflammation by inhibiting polymorphonuclear cell infiltration to the site of inflammation, shifting the cytokine milieu from proinflammatory to proresolving and increasing the nonphlogistic phagocytosis of apoptotic cells by macrophages. Here we review the evidence for molecular circuits of resolution in renal disease.