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TheScientificWorldJOURNAL
Volume 11, Pages 709-714
http://dx.doi.org/10.1100/tsw.2011.75
Mini-Review Article

The Paradigm of G Protein Receptor Transactivation: A Mechanistic Definition and Novel Example

1Discipline of Pharmacy, School of Medical Sciences, RMIT University, Melbourne, Victoria, Australia
2Diabetes Complications Group, Health Innovations Research Institute, RMIT University, Melbourne, Victoria, Australia
3Diabetes and Cell Biology Laboratory, BakerIDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
4Monash University, Departments of Medicine and Immunology, Central and Eastern Clinical School, Alfred Health, Melbourne, Victoria, Australia
5Neuropharmacology, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, Guangdong, China

Received 29 October 2010; Revised 18 February 2011; Accepted 1 March 2011

Academic Editor: Govindan Dayanithi

Copyright © 2011 Peter J. Little et al.

Citations to this Article [19 citations]

The following is the list of published articles that have cited the current article.

  • Francesca Spinella, Valentina Caprara, Valeriana Castro, Laura Rosanò, Roberta Cianfrocca, Pier Giorgio Natali, and Anna Bagnato, “Endothelin-1 induces the transactivation of vascular endothelial growth factor receptor-3 and modulates cell migration and vasculogenic mimicry in melanoma cells,” Journal of Molecular Medicine, vol. 91, no. 3, pp. 395–405, 2012. View at Publisher · View at Google Scholar
  • Danielle Kamato, Micah L. Burch, Narin Osman, Wenhua Zheng, and Peter J. Little, “Therapeutic implications of endothelin and thrombin G-protein-coupled receptor transactivation of tyrosine and serine/threonine kinase cell surface receptors,” Journal of Pharmacy and Pharmacology, vol. 65, no. 4, pp. 465–473, 2012. View at Publisher · View at Google Scholar
  • Micah L. Burch, Narin Osman, Robel Getachew, Sefaa Al-aryahi, Philip Poronnik, Wenhua Zheng, Michael A. Hill, and Peter J. Little, “G protein coupled receptor transactivation: Extending the paradigm to include serine/threonine kinase receptors,” The International Journal of Biochemistry & Cell Biology, vol. 44, no. 5, pp. 722–727, 2012. View at Publisher · View at Google Scholar
  • Peter J. Little, “GPCR responses in vascular smooth muscle can occur predominantly through dual transactivation of kinase receptors and not classical Gαq protein signalling pathways,” Life Sciences, vol. 92, no. 20-21, pp. 951–956, 2013. View at Publisher · View at Google Scholar
  • Frank Gieseler, Hendrik Ungefroren, Utz Settmacher, Morley D. Hollenberg, and Roland Kaufmann, “Proteinase-activated receptors (PARs) - focus on receptor-receptor-interactions and their physiological and pathophysiological impact,” Cell Communication and Signaling, vol. 11, 2013. View at Publisher · View at Google Scholar
  • Fabio Cattaneo, Germano Guerra, Melania Parisi, Marta De Marinis, Domenico Tafuri, Mariapia Cinelli, and Rosario Ammendola, “Cell-Surface Receptors Transactivation Mediated by G Protein-Coupled Receptors,” International Journal Of Molecular Sciences, vol. 15, no. 11, pp. 19700–19728, 2014. View at Publisher · View at Google Scholar
  • Franziska Mußbach, Petra Henklein, Martin Westermann, Utz Settmacher, Frank-D. Böhmer, and Roland Kaufmann, “Proteinase-activated receptor 1- and 4-promoted migration of Hep3B hepatocellular carcinoma cells depends on ROS formation and RTK transactivation,” Journal of Cancer Research and Clinical Oncology, 2014. View at Publisher · View at Google Scholar
  • Danielle Kamato, Muhamad Ashraf Rostam, Rebekah Bernard, Terrence J. Piva, Nitin Mantri, Daniel Guidone, Wenhua Zheng, Narin Osman, and Peter J. Little, “The expansion of GPCR transactivation-dependent signalling to include serine/threonine kinase receptors represents a new cell signalling frontier,” Cellular and Molecular Life Sciences, 2014. View at Publisher · View at Google Scholar
  • Valentina Di Liberto, Giuseppa Mudo, Kjell Fuxe, and Natale Belluardo, “Interactions Between Cholinergic and Fibroblast Growth Factor Receptors in Brain Trophism and Plasticity,” Current Protein & Peptide Science, vol. 15, no. 7, pp. 691–702, 2014. View at Publisher · View at Google Scholar
  • Paola Cipriani, Paola Di Benedetto, Piero Ruscitti, Daniela Verzella, Mariafausta Fischietti, Francesca Zazzeroni, Vasiliki Liakouli, Francesco Carubbi, Onorina Berardicurti, Edoardo Alesse, and Roberto Giacomelli, “Macitentan inhibits the transforming growth factor-β profibrotic action, blocking the signaling mediated by the ETR/TβRI complex in systemic sclerosis dermal fibroblasts,” Arthritis Research & Therapy, vol. 17, no. 1, 2015. View at Publisher · View at Google Scholar
  • Marta Gutiérrez-Rodríguez, and Rosario Herranz, “From multiple PAR1 receptor/protein interactions to their multiple therapeutic implications,” Current Topics in Medicinal Chemistry, vol. 15, no. 20, pp. 2080–2114, 2015. View at Publisher · View at Google Scholar
  • Danielle Kamato, Lyna Thach, Rebekah Bernard, Vincent Chan, Wenhua Zheng, Harveen Kaur, Margaret Brimble, Narin Osman, and Peter J. Little, “Structure, Function, Pharmacology, and Therapeutic Potential of the G Protein, Gα/q,11,” Frontiers in Cardiovascular Medicine, vol. 2, 2015. View at Publisher · View at Google Scholar
  • Franziska Zeeh, Roland Kaufmann, Utz Settmacher, Hendrik Lehnert, Morley D Hollenberg, Hendrik Ungefroren, David Witte, Thomas Gädeken, Bernhard H Rauch, Evelin Grage-Griebenow, Nadja Leinung, Sofie Joline Fromm, Stephanie Stölting, and Koichiro Mihara, “Proteinase-activated receptor 2 promotes TGF-β-dependent cell motility in pancreatic cancer cells by sustaining expression of the TGF-β type I receptor ALK5.,” Oncotarget, vol. 7, no. 27, pp. 41095–41109, 2016. View at Publisher · View at Google Scholar
  • Narges Sharifat, Ghorban Mohammad Zadeh, Mohammad-Ali Ghaffari, Parisa Dayati, Danielle Kamato, Peter J. Little, and Hossein Babaahmadi-Rezaei, “ Endothelin-1 (ET-1) stimulates carboxy terminal Smad2 phosphorylation in vascular endothelial cells by a mechanism dependent on ET receptors and de novo protein synthesis ,” Journal of Pharmacy and Pharmacology, vol. 69, no. 1, pp. 66–72, 2016. View at Publisher · View at Google Scholar
  • Allison E. Schafer, and Burns C. Blaxall, “G Protein Coupled Receptor-mediated Transactivation of Extracellular Proteases,” Journal of Cardiovascular Pharmacology, vol. 70, no. 1, pp. 10–15, 2017. View at Publisher · View at Google Scholar
  • Hendrik Ungefroren, Roland Kaufmann, Koichiro Mihara, Bernhard H. Rauch, Petra Henklein, Shirin Bonni, Morley D. Hollenberg, Frank Gieseler, David Witte, Olaf Jöhren, Utz Settmacher, and Hendrik Lehnert, “Transforming growth factor-b1/activin receptor-like kinase 5-mediated cell migration is dependent on the protein proteinase-activated receptor 2 but not on proteinase-activated receptor 2-stimulated Gq-calcium signaling,” Molecular Pharmacology, vol. 92, no. 5, pp. 519–532, 2017. View at Publisher · View at Google Scholar
  • Hendrik Ungefroren, Frank Gieseler, Roland Kaufmann, Utz Settmacher, Hendrik Lehnert, and Bernhard Rauch, “Signaling Crosstalk of TGF-β/ALK5 and PAR2/PAR1: A Complex Regulatory Network Controlling Fibrosis and Cancer,” International Journal of Molecular Sciences, vol. 19, no. 6, pp. 1568, 2018. View at Publisher · View at Google Scholar
  • Parisa Dayati, Hossein Babaahmadi Rezaei, Narges Sharifat, Danielle Kamato, and Peter J. Little, “G protein coupled receptors can transduce signals through carboxy terminal and linker region phosphorylation of Smad transcription factors,” Life Sciences, 2018. View at Publisher · View at Google Scholar
  • Wenjing Wang, Yuhui Qiao, and Zijian Li, “New Insights into Modes of GPCR Activation,” Trends in Pharmacological Sciences, 2018. View at Publisher · View at Google Scholar