Protein Disulfide Isomerase and Host-Pathogen Interaction
Figure 1
PDI and its main reactions: upper, general display of the five domains of mammalian PDI protein and showing the position of the active thioredoxin motif (WCGHC); lower, the main thiol redox reactions driven by PDI on Pt (protein/peptide) substrate containing thiols. Note that in reaction 3, the oxidation is driven by H2O2, especially in the oxidising ER compartment.
