Protein Disulfide Isomerase and Host-Pathogen Interaction

Table 1

Summary of the main PDI types and redox activity expressed in different groups of pathogens.

Pathogen group	PDI (thioredoxin motif)	Redox activity	Reference
Leishmania major	5 isoforms (CGHC, CRYC)	Oxidase-isomerase	[16, 23, 24]
amazonensis	5 isoforms (CGHC, CRYC)	Reductase-isomerase	[16, 23, 24]
infantum	5 isoforms (CGHC)	ND	[23]
braziliensis	3 isoforms (CGHC)	ND	[23]
Trypanosoma cruzi	5 isoforms (CXXC)	ND	[25, 26]
Plasmodium falciparum	4 isoforms (2x CGHC)	Oxidase-reductase	[27, 28]
Toxoplasma gondii	ND	ND	[29]
Entamoeba histolytica	1 isorform, 38 kDa (2x CGHC)	Oxidase-reductase	[30]