Human Leukocyte Antigen Class I and II Alleles and Overall Survival in Diffuse Large B-Cell Lymphoma and Follicular Lymphoma
Table 2
HLA class I and II alleles and haplotypes and their associations with overall survival among diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) patients.
DLBCL
FL
Allele/Haplotype
Status
Total no.
No. of deaths
HR (95%CI)
Total no.
No. of deaths
HR (95%CI)
HLA class I
HLA-A*01:01
Absent
107
31
1.00 (ref)
109
23
1.00 (ref)
Present
59
21
1.30 (0.74–2.26)
54
22
2.23 (1.24–4.01)
HLA-B*08:01
Absent
123
35
1.00 (ref)
123
32
1.0 (ref)
Present
42
17
1.40 (0.78–2.51)
42
14
1.39 (0.74–2.61)
HLA-Cw*07:01
Absent
111
28
1.00 (ref)
116
32
1.00 (ref)
Present
55
24
1.76 (1.01–3.05)
49
14
1.12 (0.60–2.10)
HLA-B Bw4
Absent
73
27
1.00 (ref)
55
25
1.00 (ref)
Present
106
31
0.97 (0.58–1.64)
125
23
0.36 (0.20–0.63)
HLA class II
HLA-DRB1*01:01
Absent
134
43
1.00 (ref)
118
32
1.00 (ref)
Present
32
9
0.94 (0.46–1.94)
47
14
1.12 (0.59–2.10)
HLA-DRB1*03:01
Absent
121
34
1.00 (ref)
127
33
1.00 (ref)
Present
45
18
1.41 (0.79–2.50)
38
13
1.33 (0.70–2.54)
HLA-DRB1*13
Absent
137
39
1.00 (ref)
146
47
1.00 (ref)
Present
29
13
1.34 (0.71–2.55)
19
1
0.12 (0.02–0.90)
AH 8.1
HLA-A*01-B*08-DR*03
Absent
135
40
1.00 (ref)
143
35
1.00 (ref)
Present
30
12
1.46 (0.76–2.80)
20
10
2.19 (1.08–4.45)
TNF G-308A
GG
98
26
1.00 (ref)
107
28
1.00 (ref)
GA
53
21
1.66 (0.93–2.97)
42
15
1.52 (0.81–2.86)
AA
6
3
3.81 (1.13–12.9)
4
1
0.84 (0.11–6.19)
GA/AA
59
24
1.79 (1.02–3.14)
46
16
1.45 (0.78–2.68)
HLA-A*01-B*08-DR*03-TNF-A
Absent
132
39
1.00 (ref)
135
34
1.00 (ref)
Present
29
11
1.39 (0.71–2.73)
20
10
2.13 (1.05–4.34)
All models adjusted for the risk score that combined both demographic and clinical information. The total numbers for each allele may differ due to laboratory interpretation of each allele which was done individually (e.g., ambiguous results for each allele were excluded from analysis rather than presumed to be absent).