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Volume 11 (2011), Pages 1489-1495
Short Communication

7-Chloroquinolin-4-yl Arylhydrazone Derivatives: Synthesis and Antifungal Activity

1NuQuiA—Núcleo de Química Aplicada, Centro de Ciências Químicas, Farmacêuticas e de Alimentos (CCQFA), Universidade Federal de Pelotas, Campus Universitário, Pelotas, RS, Brazil
2Laboratório de Microbiologia Oral, Faculdade de Odontologia, Universidade Federal de Pelotas, Pelotas, RS, Brazil

Received 4 May 2011; Revised 22 July 2011; Accepted 22 July 2011

Academic Editor: Paul Cos

Copyright © 2011 Auri R. Duval et al.


Fifteen 7-chloro-4-arylhydrazonequinolines have been evaluated for their in vitro antifungal activity against eight oral fungi: Candida albicans, C. parapsilosis, C. lipolytica, C. tropicalis, C. famata, C. glabrata, Rhodutorula mucilaginosa, and R. glutinis. Several compounds exhibited minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) activities comparable with the first-line drug fluconazole. These results could be considered as an important starting point for the rational design of new antifungal agents.