Review Article
Midkine in Inflammation
Table 1
Overview of the role of MK in chronic inflammatory diseases.
| Organ | Disease | Model/specimen | Publication |
| Kidney | Diabetic nephropathy | Streptozotocin-induced diabetic nephropathy | Kosugi et al. 2006 [28], Kosugi et al. 2007 [10] | Tubulointerstitial injury | Ischemia/reperfusion | Sato et al. 2001 [29], Sato et al. 2005 [30] | Drug side effects | Cisplatin-induced renal damage | Kawai et al. 2004 [31] |
| Joints | Rheumatoid arthritis | Human synovial fluid, human synovial tissue | Takada et al. 1997 [32] | Antitype II collagen antibody-induced arthritis | Maruyama et al. 2004 [11] |
| Vascular System | Atherosclerosis | Intimal hyperplasia in vein grafts | Banno et al. 2006 [33] | In-stent restenosis | Narita et al. 2008 [34] | Neointima formation in restenosis | Horiba et al. 2000 [35] |
| Colon | Crohn's disease | Human blood | Krzystek-Korpacka et al. 2010 [12] | Ulcerative colitis | Dextran-sulfate-sodium- (DSS-) induced colitis | Yuki et al. 2006 [36] |
| Central nervous system | Multiple sclerosis | Experimental autoimmune encephalomyelitis (EAE) | Liu et al. 1998 [37], Wang et al. 2008 [13] |
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