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TheScientificWorldJOURNAL
Volume 11, Pages 766-787
http://dx.doi.org/10.1100/tsw.2011.78
Review Article

Honey for Wound Healing, Ulcers, and Burns; Data Supporting Its Use in Clinical Practice

1Al-Waili's Foundation for Sciences, Chronic Wound Management and Hyperbaric Medicine, Life Support Technology Group, New York, USA
2Bee Research Chair, King Saud University, Riyadh, Saudi Arabia

Received 20 November 2010; Revised 3 March 2011; Accepted 3 March 2011

Academic Editor: Martin Goette

Copyright © 2011 Noori Al-Waili et al.

Citations to this Article [104 citations]

The following is the list of published articles that have cited the current article.

  • Mohsen Zahmatkesh, Mohammad Jalili Manesh, and Ronak Babashahabi, “Effect of Olea ointment and Acetate Mafenide on burn wounds - A randomized clinical trial.,” Iranian journal of nursing and midwifery research, vol. 20, no. 5, pp. 599–603, . View at Publisher · View at Google Scholar
  • Alexandros V. Kamaratos, Konstantinos N. Tzirogiannis, Stella A. Iraklianou, Georgios I. Panoutsopoulos, Ilias E. Kanellos, and Andreas I. Melidonis, “Manuka honey-impregnated dressings in the treatment of neuropathic diabetic foot ulcers,” International Wound Journal, pp. no–no, 2012. View at Publisher · View at Google Scholar
  • Elia Ranzato, Simona Martinotti, and Bruno Burlando, “Epithelial mesenchymal transition traits in honey-driven keratinocyte wound healing: Comparison among different honeys,” Wound Repair and Regeneration, vol. 20, no. 5, pp. 778–785, 2012. View at Publisher · View at Google Scholar
  • S. Knipping, B. Grünewald, and R. Hirt, “Erste Erfahrungen mit medizinischem Honig in der Wundbehandlung im Kopf-Hals-Bereich,” Hno, vol. 60, no. 9, pp. 830–836, 2012. View at Publisher · View at Google Scholar
  • Stefanie Oelschlaegel, Laura Pieper, Rudolf Staufenbiel, Margit Gruner, Linda Zeippert, Bernd Pieper, Isabelle Koelling-Speer, and Karl Speer, “Floral Markers of Cornflower (Centaurea cyanus) Honey and Its Peroxide Antibacterial Activity for an Alternative Treatment of Digital Dermatitis,” Journal of Agricultural and Food Chemistry, vol. 60, no. 47, pp. 11811–11820, 2012. View at Publisher · View at Google Scholar
  • Friedrich Roecken, “Options for the local therapy of open wounds to support wound healing,” Kleintierpraxis, vol. 57, no. 10, pp. 542–+, 2012. View at Publisher · View at Google Scholar
  • Romano, Sellitto, D'Argenio, and Vitaglione, “Nutraceuticals for protection and healing of gastrointestinal mucosa,” Current Medicinal Chemistry, vol. 19, no. 1, pp. 109–117, 2012. View at Publisher · View at Google Scholar
  • Noori Al-Waili, Khelod Salom, Ahmed Al-Ghamdi, and Mohammad Javed Ansari, “Antibiotic, Pesticide, and Microbial Contaminants of Honey: Human Health Hazards,” The Scientific World Journal, vol. 2012, pp. 1–9, 2012. View at Publisher · View at Google Scholar
  • Scott A. Sell, Patricia S. Wolfe, Andrew J. Spence, Isaac A. Rodriguez, Jennifer M. McCool, Rebecca L. Petrella, Koyal Garg, Jeffery J. Ericksen, and Gary L. Bowlin, “A Preliminary Study on the Potential of Manuka Honey and Platelet-Rich Plasma in Wound Healing,” International Journal of Biomaterials, vol. 2012, pp. 1–14, 2012. View at Publisher · View at Google Scholar
  • Ananya Barui, Naresh Mandal, Subhadipa Majumder, Raunak Kumar Das, Sanghamitra Sengupta, Provas Banerjee, Ajoy Kumar Ray, Chirosree RoyChaudhuri, and Jyotirmoy Chatterjee, “Assessment of molecular events during in vitro re-epithelialization under honey-alginate matrix ambience,” Materials Science and Engineering: C, vol. 33, no. 6, pp. 3418–3425, 2013. View at Publisher · View at Google Scholar
  • Saba Zuhair Hussein, Kamaruddin Mohd Yusoff, Suzana Makpol, and Yasmin Anum Mohd Yusof, “Gelam Honey Attenuates Carrageenan-Induced Rat Paw Inflammation via NF-κB Pathway,” PLoS ONE, vol. 8, no. 8, 2013. View at Publisher · View at Google Scholar
  • Reza Yaghoobi, Afshin Kazerouni, and Ory kazerouni, “Evidence for Clinical Use of Honey in Wound Healing as an Anti-bacterial, Anti-inflammatory Anti-oxidant and Anti-viral Agent: A Review,” Jundishapur Journal of Natural Pharmaceutical Products, vol. 8, no. 3, pp. 100–104, 2013. View at Publisher · View at Google Scholar
  • Peyman Boroumand, Mohammad Mahdi Zamani, Masoumeh Saeedi, Omid Rouhbakhshfar, Seyed Reza Hosseini Motlagh, and Fatemeh Aarabi Moghaddam, “Post Tonsillectomy Pain: Can Honey Reduce the Analgesic Requirements?,” Anesthesiology and Pain Medicine, vol. 3, no. 1, pp. 198–202, 2013. View at Publisher · View at Google Scholar
  • Mohammad Javed Ansari, Ahmad Al-Ghamdi, Salma Usmani, Noori S. Al-Waili, Deepak Sharma, Adgaba Nuru, and Yehya Al-Attal, “Effect of Jujube Honey on Candida albicans Growth and Biofilm Formation,” Archives of Medical Research, 2013. View at Publisher · View at Google Scholar
  • Zafar H. Israili, “Antimicrobial Properties of Honey,” American Journal of Therapeutics, pp. 1, 2013. View at Publisher · View at Google Scholar
  • Laura Cornara, “Honey in dermatology and skin care: a review,” Journal of Cosmetic Dermatology, vol. 12, no. 4, pp. 306–313, 2013. View at Publisher · View at Google Scholar
  • Khelod Salom, Ahmad Al-Ghamdi, Mohammad Javed Ansari, Ali Al-Waili, Thia Al-Waili, and Noori Al-Waili, “Honey and Cardiovascular Risk Factors, in Normal Individuals and in Patients with Diabetes Mellitus or Dyslipidemia,” Journal of Medicinal Food, vol. 16, no. 12, pp. 1063–1078, 2013. View at Publisher · View at Google Scholar
  • Yves Couquet, Alexis Desmoulière, and Marie-Laure Rigal, “Les propriétés antibactériennes et cicatrisantes du miel,” Actualités Pharmaceutiques, vol. 52, no. 531, pp. 22–25, 2013. View at Publisher · View at Google Scholar
  • Friedrich Roecken, “Honey in modern wound treatment - the renaissance of an ancient remedy,” Kleintierpraxis, vol. 58, no. 12, pp. 617–+, 2013. View at Publisher · View at Google Scholar
  • Piotr Marek Kuś, Francesca Congiu, Dariusz Teper, Zbigniew Sroka, Igor Jerković, and Carlo Ignazio Giovanni Tuberoso, “Antioxidant activity, color characteristics, total phenol content and general HPLC fingerprints of six Polish unifloral honey types,” LWT - Food Science and Technology, 2013. View at Publisher · View at Google Scholar
  • Faraidoon Haghdoost, Mohammad Mehdi Baradaran Mahdavi, Alireza Zandifar, Mohammad Hossein Sanei, Behzad Zolfaghari, and Shaghayegh Haghjooy Javanmard, “Pistacia atlantica Resin Has a Dose-Dependent Effect on Angiogenesis and Skin Burn Wound Healing in Rat,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, pp. 1–8, 2013. View at Publisher · View at Google Scholar
  • Éile Butler, Rut F. Oien, Christina Lindholm, Tobias C. Olofsson, Bo Nilson, and Alejandra Vásquez, “A pilot study investigating lactic acid bacterial symbionts from the honeybee in inhibiting human chronic wound pathogens,” International Wound Journal, 2014. View at Publisher · View at Google Scholar
  • Monika Rajput, Nandini Bhandaru, Ananya Barui, Amrita Chaudhary, Ranjan Rashmi Paul, Rabibrata Mukherjee, and Jyotirmoy Chatterjee, “Nano-patterned honey incorporated silk fibroin membranes for improving cellular compatibility,” RSC Adv., vol. 4, no. 84, pp. 44674–44688, 2014. View at Publisher · View at Google Scholar
  • N. Rothmeier, J. Abu-Jawad, J. Arnolds, D. Arweiler-Harbeck, N. Dominas, R. Stein, S. Zander, S. Lang, and S. Mattheis, “The Treatment of Chronic Wounds in the Head and Neck Area after Radiotherapy with Medical Honey,” Laryngo-Rhino-Otologie, vol. 93, no. 9, pp. 612–618, 2014. View at Publisher · View at Google Scholar
  • Charles E. Anyanechi, and Felix N. Chukwuneke, “Management of cystic surgical wound of the mandible: A comparative study analyzing closed versus open wound healing,” Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 2014. View at Publisher · View at Google Scholar
  • Saleh Mohebbi, Fatemeh Hasan Nia, Farbood Kelantari, shaqhayeqh Ebrahim Zadeh, Yaghoob Hamedi, and Reza Abd, “Efficacy of honey in reduction of post tonsillectomy pain, randomized clinical trial,” International Journal of Pediatric Otorhinolaryngology, 2014. View at Publisher · View at Google Scholar
  • José Alvarez-Suarez, Massimiliano Gasparrini, Tamara Forbes-Hernández, Luca Mazzoni, and Francesca Giampieri, “The Composition and Biological Activity of Honey: A Focus on Manuka Honey,” Foods, vol. 3, no. 3, pp. 420–432, 2014. View at Publisher · View at Google Scholar
  • Biff F. Palmer, Mark A. Perazella, and Michael J. Choi, “American Society of Nephrology Quiz and Questionnaire 2013: Electrolyte and Acid-Base,” Clinical Journal of The American Society of Nephrology, vol. 9, no. 6, pp. 1132–1137, 2014. View at Publisher · View at Google Scholar
  • Tawse, Adams, Cooke, Howard, Saeed, and Dryden, “The use of Surgihoney to prevent or eradicate bacterial colonisation in dressing oncology long vascular lines,” Journal of Wound Care, vol. 23, no. 6, pp. 338–341, 2014. View at Publisher · View at Google Scholar
  • Suhana Samat, Nor Azmi Md Nor, Fuzina Nor Hussein, and Wan Iryani Wan Ismail, “Effects of Gelam and Acacia honey acute administration on some biochemical parameters of Sprague Dawley rats,” Bmc Complementary and Alternative Medicine, vol. 14, 2014. View at Publisher · View at Google Scholar
  • Xu Tian, Li-Juan Yi, Li Ma, Lei Zhang, Guo-Min Song, and Yan Wang, “Effects of honey dressing for the treatment of DFUs: A systematic review,” International Journal of Nursing Sciences, 2014. View at Publisher · View at Google Scholar
  • Matthew Dryden, G. Lockyer, Kordo Saeed, and Jonathan Cooke, “Engineered honey: in vitro antimicrobial activity of a novel topical wound care treatment,” Journal of Global Antimicrobial Resistance, 2014. View at Publisher · View at Google Scholar
  • Mohammedaman Mama, Alemseged Abdissa, and Tsegaye Sewunet, “Antimicrobial susceptibility pattern of bacterial isolates from wound infection and their sensitivity to alternative topical agents at Jimma University Specialized Hospital, South-West Ethiopia,” Annals of Clinical Microbiology and Antimicrobials, vol. 13, 2014. View at Publisher · View at Google Scholar
  • Jing Lu, Lynne Turnbull, Catherine M. Burke, Michael Liu, Dee A. Carter, Ralf C. Schlothauer, Cynthia B. Whitchurch, and Elizabeth J. Harry, “ Manuka-type honeys can eradicate biofilms produced by Staphylococcus aureus strains with different biofilm-forming abilities ,” PeerJ, vol. 2, pp. e326, 2014. View at Publisher · View at Google Scholar
  • Omotayo Erejuwa, Siti Sulaiman, and Mohd Wahab, “Effects of Honey and Its Mechanisms of Action on the Development and Progression of Cancer,” Molecules, vol. 19, no. 2, pp. 2497–2522, 2014. View at Publisher · View at Google Scholar
  • Se Hwan Hwang, Jee Nam Song, Yeon Min Jeong, Yeon Ji Lee, and Jun Myung Kang, “The efficacy of honey for ameliorating pain after tonsillectomy: a meta-analysis,” European Archives of Oto-Rhino-Laryngology, 2014. View at Publisher · View at Google Scholar
  • Saleh Mohebbi, Fatemeh Hasan Nia, Farbood Kelantari, Sheqhayeqh Ebrahim Nejad, Yaghoob Hamedi, and Reza Abd, “Efficacy of honey in reduction of post tonsillectomy pain, randomized clinical trial,” International Journal of Pediatric Otorhinolaryngology, vol. 78, no. 11, pp. 1886–1889, 2014. View at Publisher · View at Google Scholar
  • Fatemeh Samiee rad, Akram Beheshti, Amir Abdollah Zangivand, and Younes Shafigh, “The effect of honey-impregnated human placenta membrane on burn wound healing in rat,” Comparative Clinical Pathology, 2014. View at Publisher · View at Google Scholar
  • Fahmida Alam, Md. Asiful Islam, Siew Hua Gan, and Md. Ibrahim Khalil, “Honey: A Potential Therapeutic Agent for Managing Diabetic Wounds,” Evidence-Based Complementary and Alternative Medicine, vol. 2014, pp. 1–16, 2014. View at Publisher · View at Google Scholar
  • Norman Ratcliffe, Patricia Azambuja, and Cicero Brasileiro Mello, “Recent Advances in Developing Insect Natural Products as Potential Modern Day Medicines,” Evidence-Based Complementary and Alternative Medicine, vol. 2014, pp. 1–21, 2014. View at Publisher · View at Google Scholar
  • Muzaffer Durmuş, Şükrü Öter, Hakan Çermik, Hakan Ay, Abdül Kerim Yapici, Bülent Uysal, Kemal Şimşek, and Mehmet Özler, “Effects of wound dressing materials in combination with hyperbaric oxygen on chronic wound healing,” Gulhane Medical Journal, vol. 56, no. 3, pp. 164–168, 2014. View at Publisher · View at Google Scholar
  • Luqman Hakim, Ekram Alias, Suzana Makpol, Wan Zurinah Wan Ngah, Nor Azian Morad, and Yasmin Anum Mohd Yusof, “Gelam Honey and Ginger Potentiate the Anti Cancer Effect of 5-FU against HCT 116 Colorectal Cancer Cells,” Asian Pacific Journal of Cancer Prevention, vol. 15, no. 11, pp. 4651–4657, 2014. View at Publisher · View at Google Scholar
  • Emiliano Zanier, and Bruno Bordoni, “A multidisciplinary approach to scars: A narrative review,” Journal of Multidisciplinary Healthcare, vol. 8, pp. 359–363, 2015. View at Publisher · View at Google Scholar
  • Fariborz Mokarian, Hajar-Alsadat Mansouri-Tehrani, Mohammad Rabbani-Khorasgani, Sayyed Mohsen Hosseini, Hoda Mahdavi, and Mahnaz Roayaei, “Effect of supplements: Probiotics and probiotic plus honey on blood cell counts and serum IgA in patients receiving pelvic radiotherapy,” Journal of Research in Medical Sciences, vol. 20, no. 7, pp. 679–683, 2015. View at Publisher · View at Google Scholar
  • Hye Kyung Cho, Yeon Min Jeong, Ho Seok Lee, Yeon Ji Lee, and Se Hwan Hwang, “Effects of honey on oral mucositis in patients with head and neck Cancer: A meta-analysis,” The Laryngoscope, 2015. View at Publisher · View at Google Scholar
  • Amrita Chaudhary, Swarnendu Bag, Mousumi Mandal, Sri Phani Krishna Karri, Ananya Barui, Monika Rajput, Provas Banerjee, Debdoot Sheet, and Jyotirmoy Chatterjee, “Modulating prime molecular Expressions and in vitro wound healing rate in keratinocyte (HaCaT) population under characteristic Honey dilutions,” Journal of Ethnopharmacology, 2015. View at Publisher · View at Google Scholar
  • Zohdi, Mukhtar, Said, Azmi, and Ali, “A comparative study of the wound healing properties of Gelam honey and silver sulfadiazine in diabetic rats,” IECBES 2014, Conference Proceedings - 2014 IEEE Conference on Biomedical Engineering and Sciences: "Miri, Where Engineering in Medicine and Biology and Humanity Meet", pp. 247–250, 2015. View at Publisher · View at Google Scholar
  • Wael M. Hananeh, Zuhair Bani Ismail, Musa A. Alshehabat, and Ja’afar Ali, “Review of animal models used to study effects of bee products on wound healing: findings and applications,” Bulletin of the Veterinary Institute in Pulawy, vol. 59, no. 3, 2015. View at Publisher · View at Google Scholar
  • Wael M. Hananeh, Zuhair Bani Ismail, Musa A. Alshehabat, Mahmoud Abu Abeeleh, and Ja'far Hasan Ali, “Effects of Sidr honey on second-intention healing of contaminated full-thickness skin wounds in healthy dogs,” Bulletin Of The Veterinary Institute In Pulawy, vol. 59, no. 3, pp. 433–439, 2015. View at Publisher · View at Google Scholar
  • Venkat Varalakshmi, Selvaraj A. Suganiya, and Rajendran Mala, “Fabrication and Characterization of Hybrid Sponge for Healing of Infectious Burn Wound,” Recent Patents On Nanotechnology, vol. 9, no. 3, pp. 212–221, 2015. View at Publisher · View at Google Scholar
  • Nor Hidayah Abu Bakar, Siti Norhajah Hashim, Nasir Mohamad, Rohayah Husain, Liyana Hazwani Mohd Adnan, Halim Shariff, and Nur Husna Zakaria, “Role of oxidative stress in opiate withdrawal and dependence: Exploring the potential use of honey,” Journal of Applied Pharmaceutical Science, vol. 5, no. 12, pp. 159–161, 2015. View at Publisher · View at Google Scholar
  • Joseph M. Yabes, Brian K. White, Clinton K. Murray, Carlos J. Sanchez, Katrin Mende, Miriam L. Beckius, Wendy C. Zera, Joseph C. Wenke, and Kevin S. Akers, “ In Vitro activity of Manuka Honey and polyhexamethylene biguanide on filamentous fungi and toxicity to human cell lines ,” Medical Mycology, pp. myw070, 2016. View at Publisher · View at Google Scholar
  • José Antonio González, Francisco Amich, Salvador Postigo-Mota, and José Ramón Vallejo, “Therapeutic and prophylactic uses of invertebrates in contemporary Spanish ethnoveterinary medicine,” Journal of Ethnobiology and Ethnomedicine, vol. 12, no. 1, 2016. View at Publisher · View at Google Scholar
  • Carolina Schencke, Adriana Vasconcellos, Cristian Sandoval, Paulina Torres, Francisca Acevedo, and Mariano del Sol, “Morphometric evaluation of wound healing in burns treated with Ulmo (Eucryphia cordifolia) honey alone and supplemented with ascorbic acid in guinea pig (Cavia porcellus),” Burns & Trauma, vol. 4, no. 1, 2016. View at Publisher · View at Google Scholar
  • Amanda Carys Harvey, Jeppe Madsen, C. W. Ian Douglas, Sheila MacNeil, and Steven P Armes, “Antimicrobial Graft Copolymer Gels,” Biomacromolecules, 2016. View at Publisher · View at Google Scholar
  • Redouan El-Haskoury, Afaf Amarti, Mohammad J. Ansari, Aicha Fassi Fihri, Noori S. Al-Waili, Meryem Bakour, and Badiaa Lyoussi, “Protective Effect of Morocco Carob Honey Against Lead-Induced Anemia and Hepato-Renal Toxicity,” Cellular Physiology and Biochemistry, vol. 39, no. 1, pp. 115–122, 2016. View at Publisher · View at Google Scholar
  • Roayaei, H. S. Mansouri Tehrani, and M. Rabbani Khorasgani, “Effects of probiotics with or without honey on radiation-induced diarrhea,” Iranian Journal of Radiation Research, vol. 14, no. 3, pp. 205–213, 2016. View at Publisher · View at Google Scholar
  • Momin, Khanekar, Mhatre, and Kurhade, “Novel biodegradable hydrogel sponge containing curcumin and honey for wound healing,” Journal of Wound Care, vol. 25, no. 6, pp. 364–372, 2016. View at Publisher · View at Google Scholar
  • Rita Langasco, Gianpiera Spada, Sakine Tuncay Tanriverdi, Giovanna Rassu, Paolo Giunchedi, Özgen Özer, and Elisabetta Gavini, “Bio-based topical system for enhanced salicylic acid delivery: preparation and performance of gels,” Journal of Pharmacy and Pharmacology, 2016. View at Publisher · View at Google Scholar
  • Ramya Kateel, Prabha Adhikari, Alfred J. Augustine, and Sheetal Ullal, “Topical honey for the treatment of diabetic foot ulcer: A systematic review,” Complementary Therapies in Clinical Practice, 2016. View at Publisher · View at Google Scholar
  • Tobias C. Olofsson, Éile Butler, Christina Lindholm, Bo Nilson, Per Michanek, and Alejandra Vásquez, “Fighting Off Wound Pathogens in Horses with Honeybee Lactic Acid Bacteria,” Current Microbiology, 2016. View at Publisher · View at Google Scholar
  • Motuma Adimasu Abeshu, and Bekesho Geleta, “Medicinal uses of honey,” Biology and Medicine, vol. 8, no. 2, 2016. View at Publisher · View at Google Scholar
  • Euis Reni Yuslianti, Boy M. Bachtia, Dewi F. Suniart, and Afifah B. Sutjiat, “Effect of Rambutan Honey (Nephelium lappaceum) Acute Administration on Mortality, Body Weight, Toxicity Symptoms and Relative Organ Weight of Swiss Websters Mice,” Research Journal of Toxins, vol. 8, no. 1, pp. 1–7, 2016. View at Publisher · View at Google Scholar
  • Alia Md Yusof, Norzana Abd Ghafar, Taty Anna Kamarudin, Chua Kien Hui, and Yasmin Anum Mohd Yusof, “Gelam honey potentiates ex vivo corneal keratocytes proliferation with desirable phenotype expression,” BMC Complementary and Alternative Medicine, vol. 16, no. 1, 2016. View at Publisher · View at Google Scholar
  • A. Lal, K. Chohan, A. Chohan, and A. Chakravarti, “Role of honey after tonsillectomy: a systematic review and meta-analysis of randomised controlled trials,” Clinical Otolaryngology, vol. 42, no. 3, pp. 651–660, 2016. View at Publisher · View at Google Scholar
  • Abdullah E. Kattan, Feras AlShomer, Abdulaziz K. Alhujayri, Abdullah Addar, and Albaraa Aljerian, “Current knowledge of burn injury first aid practices and applied traditional remedies: a nationwide survey,” Burns & Trauma, vol. 4, no. 1, 2016. View at Publisher · View at Google Scholar
  • Faraidoon Haghdoost, Behzad Zolfaghari, Mohammad Hossein Sanei, Alireza Zandifar, Mohammad Mehdi Baradaran Mahdavi, Somaye Najafi, Navid Manouchehri, and Shaghayegh Haghjooy Javanmard, “The effect of quercus brantii gall extract on burn wound healing in rat,” Iranian Journal of Basic Medical Sciences, vol. 19, no. 10, pp. 1144–1150, 2016. View at Publisher · View at Google Scholar
  • Hossein Karegar-Borzi, Mehdi Salehi, and Roja Rahimi, “Laūq: A Sustained-Release Dosage Form for Respiratory Disorders in Traditional Persian Medicine,” Journal of Evidence-Based Complementary and Alternative Medicine, vol. 21, no. 1, pp. 63–70, 2016. View at Publisher · View at Google Scholar
  • Ahmad Oryan, Esmat Alemzadeh, and Ali Moshiri, “Biological Properties and Therapeutic Activities of Honey in Wound Healing: A narrative review and meta-analysis,” Journal of Tissue Viability, 2016. View at Publisher · View at Google Scholar
  • F. Alihosseini, “Plant-based compounds for antimicrobial textiles,” Antimicrobial Textiles, pp. 155–195, 2016. View at Publisher · View at Google Scholar
  • Nihar Dash, Debadatta Panigrahi, and Mansour Al-Zarouni, “Antimicrobial Effect of Honey from the Arabian Gulf Region against Bacterial Isolates from Pus and Wound Swabs,” Advances in Microbiology, vol. 06, no. 10, pp. 745–752, 2016. View at Publisher · View at Google Scholar
  • Katherine R. Hixon, Tracy Lu, Marissa N. Carletta, Sarah H. McBride-Gagyi, Blythe E. Janowiak, and Scott A. Sell, “ A preliminary in vitro evaluation of the bioactive potential of cryogel scaffolds incorporated with Manuka honey for the treatment of chronic bone infections ,” Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2017. View at Publisher · View at Google Scholar
  • Vafa Baradaran Rahimi, Reza Shirazinia, Narges Fereydouni, Parvin Zamani, Sousan Darroudi, Amir Hossein Sahebkar, and Vahid Reza Askari, “Comparison of honey and dextrose solution on post-operative peritoneal adhesion in rat model,” Biomedicine & Pharmacotherapy, vol. 92, pp. 849–855, 2017. View at Publisher · View at Google Scholar
  • Hana Scepankova, Jorge A. Saraiva, and Letícia M. Estevinho, “Honey Health Benefits and Uses in Medicine,” Bee Products - Chemical and Biological Properties, pp. 83–96, 2017. View at Publisher · View at Google Scholar
  • Abid Nordin, Nur Qisya Afifah Veronica Sainik, Mohamed S. Zulfarina, Isa Naina-Mohamed, Aminuddin Saim, and Ruszymah Bt Hj Idrus, “Honey and Epithelial to Mesenchymal Transition in Wound Healing: An Evidence-Based Review,” Wound Medicine, 2017. View at Publisher · View at Google Scholar
  • Laura Cornara, Marco Biagi, Jianbo Xiao, and Bruno Burlando, “Therapeutic Properties of Bioactive Compounds from Different Honeybee Products,” Frontiers in Pharmacology, vol. 8, 2017. View at Publisher · View at Google Scholar
  • R Heru Prasetyo, and Eka Pramyrtha Hestianah, “Honey can repairing damage of liver tissue due to protein energy malnutrition through induction of endogenous stem cells.,” Veterinary world, vol. 10, no. 6, pp. 711–715, 2017. View at Publisher · View at Google Scholar
  • Mitchell D. Flurry, Kelsie L. Herring, Logan W. Carr, Randy M. Hauck, and John D. Potochny, “Salve and Burdock,” Advances in Skin & Wound Care, vol. 30, no. 5, pp. 213–217, 2017. View at Publisher · View at Google Scholar
  • Matthew Dryden, “Reactive oxygen therapy,” Current Opinion in Infectious Diseases, vol. 30, no. 2, pp. 143–149, 2017. View at Publisher · View at Google Scholar
  • Swapna Gannabathula, Geoffrey W. Krissansen, Liana Bisson-Rowe, Margot Skinner, Gregor Steinhorn, and Ralf Schlothauer, “Correlation of the immunostimulatory activities of honeys with their contents of identified bioactives,” Food Chemistry, vol. 221, pp. 39–46, 2017. View at Publisher · View at Google Scholar
  • Matthew Dryden, Jonathan Cooke, Rami Salib, Rebecca Holding, Sylvia L.F. Pender, and Jill Brooks, “Hot topics in reactive oxygen therapy: Antimicrobial and immunological mechanisms, safety and clinical applications,” Journal of Global Antimicrobial Resistance, vol. 8, pp. 194–198, 2017. View at Publisher · View at Google Scholar
  • Supamas Napavichayanun, and Pornanong Aramwit, “Effect of animal products and extracts on wound healing promotion in topical applications: a review,” Journal of Biomaterials Science, Polymer Edition, pp. 1–27, 2017. View at Publisher · View at Google Scholar
  • Mohd Azri Abd Jalil, Abdul Razak Kasmuri, and Hazrina Hadi, “Stingless Bee Honey, the Natural Wound Healer: A Review,” Skin Pharmacology and Physiology, pp. 66–75, 2017. View at Publisher · View at Google Scholar
  • Brian Condon, Dorne Yager, J. Edwards, Nicolette Prevost, Sunghyun Nam, and Doug Hinchliffe, “Induction of Low-Level Hydrogen Peroxide Generation by Unbleached Cotton Nonwovens as Potential Wound Dressing Materials,” Journal of Functional Biomaterials, vol. 8, no. 1, pp. 9, 2017. View at Publisher · View at Google Scholar
  • Rabia Shabir Ahmad, Muhammad Bilal Hussain, Farhan Saeed, Marwa Waheed, and Tabussam Tufail, “Phytochemistry, Metabolism and Ethnomedical Scenerio of Honey: A Concurrent Review,” International Journal of Food Properties, 2017. View at Publisher · View at Google Scholar
  • Mg Miguel, Md Antunes, and Ml Faleiro, “Honey as a Complementary Medicine,” Integrative Medicine Insights, vol. 12, pp. 117863371770286, 2017. View at Publisher · View at Google Scholar
  • Ahmad Oryan, and Esmat Alemzadeh, “Potential Mechanisms and Application of Honeybee Products in Wound Management: Wound Healing by Apitherapy,” 2017. View at Publisher · View at Google Scholar
  • Matthew S. Dryden, “Reactive Oxygen Species Treatment in the Management of Wounds,” 2017. View at Publisher · View at Google Scholar
  • Sami K. Saikaly, and Amor Khachemoune, “Honey and Wound Healing: An Update,” American Journal of Clinical Dermatology, 2017. View at Publisher · View at Google Scholar
  • H.A. Azis, M. Taher, A.S. Ahmed, W.M.A.W. Sulaiman, D. Susanti, S.R. Chowdhury, and Z.A. Zakaria, “In vitro and In vivo wound healing studies of methanolic fraction of Centella asiatica extract,” South African Journal of Botany, vol. 108, pp. 163–174, 2017. View at Publisher · View at Google Scholar
  • Katherine R. Hixon, Tracy Lu, Sarah H. McBride-Gagyi, Blythe E. Janowiak, and Scott A. Sell, “A Comparison of Tissue Engineering Scaffolds Incorporated with Manuka Honey of Varying UMF,” BioMed Research International, vol. 2017, pp. 1–12, 2017. View at Publisher · View at Google Scholar
  • Syarida H. Safii, Geoffrey R. Tompkins, and Warwick J. Duncan, “Periodontal Application of Manuka Honey: Antimicrobial and Demineralising Effects In Vitro,” International Journal of Dentistry, vol. 2017, pp. 1–8, 2017. View at Publisher · View at Google Scholar
  • Faheemmaqbool, Kamal Niaz, Mohammad Abdollahi, and Haji Bahadar, “Health benefits of manuka honey as an essential constituent for tissue regeneration,” Current Drug Metabolism, vol. 18, no. 10, pp. 881–892, 2017. View at Publisher · View at Google Scholar
  • Abid Nordin, Norazzila Omar, Nur Qisya Afifah Veronica Sainik, Shiplu Roy Chowdhury, Eshaifol Omar, Aminuddin Bin Saim, and Ruszymah Bt Hj Idrus, “Low Dose Stingless Bee Honey Increases Viability of Human Dermal Fibroblasts That Could Potentially Promote Wound Healing,” Wound Medicine, 2018. View at Publisher · View at Google Scholar
  • Nuraldeen M. Al-Khanati, and Yasser Al-Moudallal, “Effect of Intrasocket Application of Manuka Honey on Postsurgical Pain of Impacted Mandibular Third Molars Surgery: Split-Mouth Randomized Controlled Trial,” Journal of Maxillofacial and Oral Surgery, 2018. View at Publisher · View at Google Scholar
  • Maryam Hatami, Mahdieh Mirjalili, Vida Ayatollahi, Sedighe Vaziribozorg, and Vahid Zand, “Comparing the Efficacy of Peritonsillar Injection of Tramadol With Honey in Controlling Post-Tonsillectomy Pain in Adults,” Journal of Craniofacial Surgery, vol. 29, no. 4, pp. e384–e387, 2018. View at Publisher · View at Google Scholar
  • Benjamin Minden-Birkenmaier, and Gary Bowlin, “Honey-Based Templates in Wound Healing and Tissue Engineering,” Bioengineering, vol. 5, no. 2, pp. 46, 2018. View at Publisher · View at Google Scholar
  • Fatemeh Samiee-rad, Seyed Masoud Hashemi, Amir Abdollah Zangivand, and Kamran Soleimanitadi, “Effect of acacia honey-impregnated placenta membrane on pain and burn wound repair,” Comparative Clinical Pathology, 2018. View at Publisher · View at Google Scholar
  • Gabriel M. Virador, Lola de Marcos, and Victoria M. Virador, “Skin Wound Healing: Refractory Wounds and Novel Solutions,” 2018. View at Publisher · View at Google Scholar
  • Mohd Yusuf, “Application of Recombinant Insect Products in Modern Research: An Overview,” Trends in Insect Molecular Biology and Biotechnology, pp. 283–294, 2018. View at Publisher · View at Google Scholar
  • Ana M. P. Oliveira, Joana S. P. Devesa, and Peter B. Hill, “ In vitro efficacy of a honey-based gel against canine clinical isolates of Staphylococcus pseudintermedius and Malassezia pachydermatis ,” Veterinary Dermatology, 2018. View at Publisher · View at Google Scholar
  • Emma Bateman, Richard Logan, Rachel Gibson, and Dorothy Keefe, “Mouth,” Textbook of Palliative Care, pp. 1–17, 2018. View at Publisher · View at Google Scholar
  • S. C. Lokossou, H. Yédomonhan, G. M. Tossou, and F. P. Tchobo, “Utilisations thérapeutiques du miel par les populations locales du Bénin,” Phytothérapie, vol. 15, no. 6, pp. 339–345, 2018. View at Publisher · View at Google Scholar
  • Nur Husna Zakaria, Halim Shariff, Liyana Hazwani Mohd Adnan, Siti Norhajah Hashim, Mohd Ululilmie, Nasir Mohama, Zulkifli Mustapha, Nor Hidayah Abu Bakar, Rohayah Husain, and Khairi Che Mat, “Honey potentially mitigates morphine analgesic tolerance and physical dependence in rats,” Bangladesh Journal of Medical Science, vol. 17, no. 1, pp. 138–143, 2018. View at Publisher · View at Google Scholar