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Volume 11, Pages 1886-1892
Research Article

Comparative Effects of Triflusal, S-Adenosylmethionine, and Dextromethorphan over Intestinal Ischemia/Reperfusion Injury

1Departamento de Fisiología, Facultad de Medicina, UANL, Avenida Francisco I. Madero y Dr. Eduardo Aguirre Pequeño S/No, Col. Mitras Centro, 64460 Monterrey, NL, Mexico
2Departamento de Medicina Interna, Facultad de Medicina, Universidad Autónoma de Nuevo León, 64460 Monterrey, NL, Mexico
3Unidad de Hígado, Departamento de Medicina Interna, Facultad de Medicina, Universidad Autónoma de Nuevo León, 64460 Monterrey, NL, Mexico
4Servicio de Anatomía Patológica y Citopatología, Hospital Universitario “José Eleuterio González,” 64460 Monterrey, NL, Mexico

Received 27 August 2011; Accepted 12 October 2011

Academic Editor: Huaxin Sheng

Copyright © 2011 Carlos R. Cámara-Lemarroy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Ischemia/reperfusion (I/R) is a condition that stimulates an intense inflammatory response. No ideal treatment exists. Triflusal is an antiplatelet salicylate derivative with anti-inflammatory effects. S-adenosylmethionine is a metabolic precursor for glutathione, an endogenous antioxidant. Dextromethorphan is a low-affinity N-methyl-D-aspartate receptor inhibitor. There is evidence that these agents modulate some of the pathways involved in I/R physiopathology. Intestinal I/R was induced in rats by clamping the superior mesenteric artery for 60 minutes, followed by 60 minutes of reperfusion. Rats either received saline or the drugs studied. At the end of the procedure, serum concentrations of tumor necrosis factor-alpha (TNF-alpha), malonaldehyde (MDA), and total antioxidant capacity (TAC) were determined and intestinal morphology analyzed. I/R resulted in tissue damage, serum TNF-alpha and MDA elevations, and depletion of TAC. All drugs showed tissue protection. Only triflusal reduced TNF-alpha levels. All drugs lowered MDA levels, but only triflusal and S-adenosylmethionine maintained the serum TAC.