Clinical Study
Pro- and Antiapoptotic Markers in Upper Tract Urothelial Carcinoma
Associated with Balkan Endemic Nephropathy
Table 3
Expression of apoptosis-related markers in UTUC associated with BEN and in control UTUC.
| | Molecular marker | BEN () | Control () | | | Expression (%) |
| | Survivin | | | N.S. | | Not altered | 18 (40.9) | 32 (52.5) | | | Altered | 26 (59.1) | 29 (47.5) | |
| | Bcl-2 | | | N.S. | | Not altered | 37 (84.1) | 52 (85.2) | | | Altered | 7 (15.9) | 9 (14.8) | |
| | Bax | | | 0.05 | | Not altered | 24 (54.5) | 20 (32.8) | | | Altered | 20 (45.5) | 41 (67.2) | |
| | Fas | | | N.S. | | Not altered | 21 (47.7) | 39 (63.9) | | | Altered | 23 (52.3) | 22 (36.1) | |
| | Caspase 3* | | | N.S. | | X ± SD | 3.5 ± 9.9 | 1.9 ± 4.9 | |
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χ 2 test was performed
*Mann Whitney U test was performed
N.S.: no significance.
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