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TheScientificWorldJOURNAL
Volume 11 (2011), Pages 2620-2634
http://dx.doi.org/10.1100/2011/768948
Review Article

Regulatory Immunotherapy in Bone Marrow Transplantation

Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA

Received 10 August 2011; Accepted 12 October 2011

Academic Editors: N. Miyahara, Y. Renaudineau, and J. Sidney

Copyright © 2011 Vanessa Morales-Tirado et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Every year individuals receive hematopoietic stem cell transplantation (HSCT) to eradicate malignant and nonmalignant disease. The immunobiology of allotransplantation is an area of ongoing discovery, from the recipient's conditioning treatment prior to the transplant to the donor cell populations responsible for engraftment, graft-versus-host disease, and graft-versus-tumor effect. In this review, we focus on donor-type immunoregulatory T cells, namely, natural killer T cells (NKT) and regulatory T cells (Treg), and their current and potential roles in tolerance induction after allogeneic HSCT.