Regulatory Immunotherapy in Bone Marrow Transplantation

Figure 1

Model for host-donor immunoregulation after nonmyeloablative BMT. Figure illustrating key regulatory populations in host and donor and the potential for interactive regulation across major and minor histocompatibility complex barriers after allogeneic BMT. NKT cells, through potent of cytokines secretion including IL-4, can directly regulate the effector T cells responsible for GVHD; NKT cells can also induce the activation and proliferation of Treg from the donor graft, which in turn regulate effector T-cell-mediated GVHD. NKT: natural killer T; Th2: T-helper type 2; Tr1: Foxp3^negCD4⁺IL-10⁺ regulatory T cell; IL-4: interleukin-4.