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TheScientificWorldJOURNAL
Volume 11, Pages 1316-1324
http://dx.doi.org/10.1100/tsw.2011.125
Case Study

Type B Lactic Acidosis Secondary to Malignancy: Case Report, Review of Published Cases, Insights into Pathogenesis, and Prospects for Therapy

1Department of Medicine, John H. Stroger Hospital of Cook County, Chicago, Illinois, USA
2Division of Nephrology, John H. Stroger Hospital of Cook County, Chicago, Illinois, USA

Received 31 January 2011; Revised 10 June 2011; Accepted 10 June 2011

Academic Editor: Daniel Batlle

Copyright © 2011 Juan P. Ruiz et al.

Citations to this Article [38 citations]

The following is the list of published articles that have cited the current article.

  • Georges C. Elhomsy, Vijay Eranki, Stewart G. Albert, Mark J. Fesler, Stacey M. Parker, Amanda G. Michael, and George T. Griffing, “"Hyper-Warburgism," a Cause of Asymptomatic Hypoglycemia with Lactic Acidosis in a Patient with Non-Hodgkin's Lymphoma,” Journal Of Clinical Endocrinology & Metabolism, vol. 97, no. 12, pp. 4311–4316, 2012. View at Publisher · View at Google Scholar
  • Hazem El-Osta, Abdulrahman Abdulbaki, Prakash Peddi, Amol Takalkar, James Cotelingam, Diana Veillon, Andres Vargas, Nuri Akkus, and Gerhard C. Hildebrandt, “Lactic Acidosis and Atrial Tachycardia: Unusual Presentations of Disseminated Burkitt-Like Lymphoma,” Journal of Cancer Therapy, vol. 03, no. 05, pp. 589–594, 2012. View at Publisher · View at Google Scholar
  • Ubaldo E. Martinez-Outschoorn, Diana Whitaker-Menezes, Matias Valsecchi, Maria P. Martinez-Cantarin, Alina Dulau-Florea, Jerald Gong, Anthony Howell, Neal Flomenberg, Richard G. Pestell, John Wagner, Cecilia Arana-Yi, Manish Sharma, Federica Sotgia, and Michael P. Lisanti, “Reverse Warburg Effect in a Patient With Aggressive B-Cell Lymphoma: Is Lactic Acidosis a Paraneoplastic Syndrome?,” Seminars in Oncology, vol. 40, no. 4, pp. 403–418, 2013. View at Publisher · View at Google Scholar
  • Patrick Sia, Troy J. Plumb, and Jennifer A. Fillaus, “Type B Lactic Acidosis Associated With Multiple Myeloma,” American Journal of Kidney Diseases, 2013. View at Publisher · View at Google Scholar
  • Patrick Tang, Anamarija M. Perry, and Mojtaba Akhtari, “A Case of Type B Lactic Acidosis in Multiple Myeloma,” Clinical Lymphoma Myeloma and Leukemia, vol. 13, no. 1, pp. 80–82, 2013. View at Publisher · View at Google Scholar
  • Lixue Dong, Eric Dean, Li V. Yang, and Zhigang Li, “Acidosis Decreases c-Myc Oncogene Expression in Human Lymphoma Cells: A Role for the Proton-Sensing G Protein-Coupled Receptor TDAG8,” International Journal of Molecular Sciences, vol. 14, no. 10, pp. 20236–20255, 2013. View at Publisher · View at Google Scholar
  • B. Mégarbane, “Acidoses lactiques graves en dehors des états de choc,” Réanimation, vol. 22, no. S2, pp. 435–445, 2013. View at Publisher · View at Google Scholar
  • Michael P. Lisanti, Diana Whitaker-Menezes, Cecilia Arana-Yi, Federica Sotgia, Matias Valsecchi, Maria P. Martinez-Cantarin, Anthony Howell, Manish Sharma, Alina Dulau-Florea, Jerald Gong, Neal Flomenberg, Richard G. Pestell, Ubaldo E. Martinez-Outschoorn, and John Wagner, “Reverse Warburg Effect in a Patient With Aggressive B-Cell Lymphoma: Is Lactic Acidosis a Paraneoplastic Syndrome?,” Seminars In Oncology, vol. 40, no. 4, pp. 403–418, 2013. View at Publisher · View at Google Scholar
  • Demelza Hoogwerf, Jaap van Doorn, and Eduard Maartense, “The insulin-like growth factor-system in a patient with diffuse large B-cell non-hodgkin's lymphoma and lactic acidosis,” Annals of Clinical Biochemistry, vol. 50, no. 2, pp. 169–172, 2013. View at Publisher · View at Google Scholar
  • Georges Tanios, Ines M. Aranguren, Jack S. Goldstein, and Chirag B. Patel, “Diffuse large B-cell lymphoma: A metabolic disorder?,” American Journal of Case Reports, vol. 14, pp. 518–525, 2013. View at Publisher · View at Google Scholar
  • Brucculeri, Urso, and Caimi, “The role of lactate besides the lactic acidosis,” Clinica Terapeutica, vol. 164, no. 3, pp. e223–e238, 2013. View at Publisher · View at Google Scholar
  • Jeanne Held-Warmkessel, and Deena Damsky Dell, “Lactic Acidosis in Patients With Cancer,” Clinical Journal of Oncology Nursing, vol. 18, no. 5, pp. 592–594, 2014. View at Publisher · View at Google Scholar
  • Neda Hashemi-Sadraei, Jorge D. Machicado, Rohan Gupta, and Julio A. Huapaya, “Lactic Acidosis in Gastric Cancer,” Journal of Gastrointestinal Cancer, 2014. View at Publisher · View at Google Scholar
  • A. Ouchikhe, J.-L. Le Bivic, O. Longuet, J. Maindivide, and J.-F. Vincent, “Une acidose lactique sévère révélatrice d’une hémopathie maligne,” Annales Françaises d'Anesthésie et de Réanimation, 2014. View at Publisher · View at Google Scholar
  • Agata Bronisz, Magdalena Spychalska, and Małgorzata Szafrańska, “Lactic acidosis occurrence during exercises in the smoke chamber in a 53-year-old firefighter with no significant medical history,” International Journal of Occupational Medicine and Environmental Health, 2014. View at Publisher · View at Google Scholar
  • Robert J. Greiner, Stacey Peterson-Carmichael, Jennifer A. Rothman, Kenneth W. Gow, Robert F. Tamburro, and Raymond Barfieldvol. 3, pp. 343–361, 2014. View at Publisher · View at Google Scholar
  • Randy L. Luciano, and Ursula C. Brewster, “Kidney Involvement in Leukemia and Lymphoma,” Advances in Chronic Kidney Disease, vol. 21, no. 1, pp. 27–35, 2014. View at Publisher · View at Google Scholar
  • Arvind Kumar, and Vinod Raina, “Non-Hodgkins lymphoma with lactic acidosis at presentation: A case report of a rare oncologic emergency,” Indian Journal of Medical and Paediatric Oncology, vol. 35, no. 1, pp. 83–85, 2014. View at Publisher · View at Google Scholar
  • Anirban Ganguli, Deirdre Sawinski, and Jeffrey S. Berns, “Kidney diseases associated with haematological cancers,” Nature Reviews Nephrology, 2015. View at Publisher · View at Google Scholar
  • Meng Chen, Tiffany Y. Kim, and Antonio M. Pessegueiro, “Elevated lactate levels in a non-critically ill patient,” JAMA - Journal of the American Medical Association, vol. 313, no. 8, pp. 849–850, 2015. View at Publisher · View at Google Scholar
  • Megha Garg, Brian E. Lee, Kelly McGarry, Shamlal Mangray, and Jorge J. Castillo, “CD20-negative diffuse large B-cell lymphoma presenting with lactic acidosis,” American Journal of Hematology, vol. 90, no. 3, pp. E49–E50, 2015. View at Publisher · View at Google Scholar
  • Jeffrey D. Krimmel, and Clifford D. Packer, “Type B Lactic Acidosis in a Patient with Gastric Adenocarcinoma and Extensive Hepatic Metastases,” Medical Principles And Practice, vol. 24, no. 4, pp. 391–393, 2015. View at Publisher · View at Google Scholar
  • Andrew John Gardner, and John Griffiths, “A case of type B lactic acidosis as a complication of chronic myelomonocytic leukaemia: A case report and review of the literature,” Journal of Medical Case Reports, vol. 9, no. 1, 2015. View at Publisher · View at Google Scholar
  • Jutaro Murase, Tadashi Miyamori, Tomohiro Nishi, Junko Koyanagi, Masayuki Sato, and Tadashi Yamagishi, “Marked lactate dehydrogenase elevation and tachypnea due to lactic acidosis in a patient with terminal stage prostate cancer: the first report in Japan,” Palliative Care Research, vol. 10, no. 3, pp. 539–542, 2015. View at Publisher · View at Google Scholar
  • Panagiotis J. Vlachostergios, Katerina G. Oikonomou, Eugene Gibilaro, and George Apergis, “Elevated lactic acid is a negative prognostic factor in metastatic lung cancer,” Cancer Biomarkers, vol. 15, no. 6, pp. 725–734, 2015. View at Publisher · View at Google Scholar
  • Sameer Y. Abdullah, Moaath K. Ali, and Marwa M. Sabha, “Type-B lactic acidosis associated with progressive multiple myeloma,” Saudi Medical Journal, vol. 36, no. 2, pp. 239–242, 2015. View at Publisher · View at Google Scholar
  • Evan S. Schwarz, “Therapeutic Approach to the Critically Poisoned Patient,” Critical Care Toxicology, pp. 1–37, 2016. View at Publisher · View at Google Scholar
  • Jesús Salvador Sánchez-Díaz, Enrique Monares-Zepeda, Enrique Antonio Martínez-Rodríguez, Jorge Samuel Cortés-Román, Oscar Torres-Aguilar, Karla Gabriela Peniche-Moguel, Susana Patricia Díaz-Gutiérrez, Eusebio Pin-Gutiérrez, Gerardo Rivera-Solís, Rosalba Carolina García-Méndez, Juan Marcelo Huanca-Pacaje, and María Verónica Calyeca-Sánchez, “Acidosis láctica por metformina: reporte de caso,” Revista Colombiana de Anestesiología, 2017. View at Publisher · View at Google Scholar
  • Jesús Salvador Sánchez-Díaz, Enrique Monares-Zepeda, Enrique Antonio Martínez-Rodríguez, Jorge Samuel Cortés-Román, Oscar Torres-Aguilar, Karla Gabriela Peniche-Moguel, Susana Patricia Díaz-Gutiérrez, Eusebio Pin-Gutiérrez, Gerardo Rivera-Solís, Rosalba Carolina García-Méndez, Juan Marcelo Huanca-Pacaje, and María Verónica Calyeca-Sánchez, “Metformin-related lactic acidosis: Case report,” Colombian Journal of Anesthesiology, 2017. View at Publisher · View at Google Scholar
  • Evan S. Schwarz, “Therapeutic Approach to the Critically Poisoned Patient,” Critical Care Toxicology, pp. 43–78, 2017. View at Publisher · View at Google Scholar
  • Calvin R. Justus, Edward J. Sanderlin, Lixue Dong, Tianai Sun, Jen-Tsan Chi, Kvin Lertpiriyapong, and Li V. Yang, “Contextual tumor suppressor function of T cell death-associated gene 8 (TDAG8) in hematological malignancies,” Journal of Translational Medicine, vol. 15, no. 1, 2017. View at Publisher · View at Google Scholar
  • Jesús Salvador Sánchez-Díaz, Enrique Monares-Zepeda, Enrique Antonio Martínez-Rodríguez, Jorge Samuel Cortés-Román, Oscar Torres-Aguilar, Karla Gabriela Peniche-Moguel, Susana Patricia Díaz-Gutiérrez, Eusebio Pin-Gutiérrez, Gerardo Rivera-Solís, Rosalba Carolina García-Méndez, Juan Marcelo Huanca-Pacaje, and María Verónica Calyeca-Sánchez, “Metformin-related lactic acidosis: Case report☆,” Colombian Journal of Anesthesiology, vol. 45, no. 4, pp. 353–359, 2017. View at Publisher · View at Google Scholar
  • Marco Mejia, Ariel Perez, Harold Watson, Daniel Sanchez, Jorge Parellada, Mario Madruga, and S. J. Carlan, “Successful Treatment of Severe Type B Lactic Acidosis in a Patient with HIV/AIDS-Associated High-Grade NHL,” Case Reports in Immunology, vol. 2018, pp. 1–4, 2018. View at Publisher · View at Google Scholar
  • Clément Brault, Yoann Zerbib, Caroline Delette, Julien Marc, Bérengère Gruson, Jean P. Marolleau, and Julien Maizel, “The Warburg Effect as a Type B Lactic Acidosis in a Patient With Acute Myeloid Leukemia: A Diagnostic Challenge for Clinicians,” Frontiers in Oncology, vol. 8, 2018. View at Publisher · View at Google Scholar
  • Brian James Kirsch, Shu-Jyuan Chang, and Anne Le, “Non-Hodgkin Lymphoma Metabolism,” The Heterogeneity of Cancer Metabolism, vol. 1063, pp. 95–106, 2018. View at Publisher · View at Google Scholar
  • C. Gheux, C. Brault, A. Henry, M. Drucbert, J. Schmidt, and P. Duhaut, “Effet Warburg au cours d’une dermatomyosite,” La Revue de Médecine Interne, vol. 39, pp. A230–A231, 2018. View at Publisher · View at Google Scholar
  • John Hausken, Ellen M. Haave, Håkon Haugaa, Else M. Løberg, and Ulf E. Kongsgaard, “A patient with solid gynecologic cancer causing lactic acidosis, severe hypercalcemia, and hypoglycemia,” Clinical Case Reports, 2018. View at Publisher · View at Google Scholar
  • Ahsan Wahab, Kavitha Kesari, Susan J. Smith, Yang Liu, and Stefan K. Barta, “Type B lactic acidosis, an uncommon paraneoplastic syndrome,” Cancer Biology & Therapy, pp. 1–4, 2018. View at Publisher · View at Google Scholar