The Nicotinic Acetylcholine Receptor as a Target for Antidepressant Drug Development

Table 1

Evidence for MEC/S-MEC in mouse models of depression.

Study	Compound(s)	MEC/s-MEC dose	Results
Popik et al. [35]	MEC + CTP; MEC + IMI	0.025 mg/kg	Improved FST
Rabenstein et al. [36]	MEC	1 mg/kg	Improved FST and TST
Caldarone et al. [37]	MEC	0.50, 0.75, or 1.0 mg/kg	Improved FST/TST
	MEC + AMI		Further improved FST/TST
Andreasen et al. [38]	MEC	3 or 10 mg/kg^a	Improved FST/TST
Andreasen and Redrobe [20]	MEC + CTP	1, 3 mg/kg	No effect on FST/TST
	MEC + REB
Mineur et al. [39]	MEC	1 mg/kg	Improved FST/TST
Lippiello et al. [40]	S-MEC	3 mg/kg	Improved FST

Notes: ^a1–10 mg/kg doses tested, and only doses at 3 and 10 mg/kg with improved FST/TST.
Abbreviations: MEC: mecamylamine; CTP: citalopram; IMI: imipramine; AMI: amitriptyline: REB: reboxetine; S-MEC: s-mecamylamine; FST: forced swim test; TST: tail suspension test.