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The Scientific World Journal
Volume 2012, Article ID 126723, 8 pages
http://dx.doi.org/10.1100/2012/126723
Research Article

Temperature-Sensitive Gels for Intratumoral Delivery of β-Lapachone: Effect of Cyclodextrins and Ethanol

1Faculdade de Ciências da Saúde, Universidade de Brasília (UnB), Campus Universitário Darcy Ribeiro, 70910-900 Brasília-DF, Brazil
2Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Campus Vida, Universidad de Santiago, 15782 Santiago de Compostela, Spain

Received 20 October 2011; Accepted 15 January 2012

Academic Editors: D. Quintanar-Guerrero and A. Savaser

Copyright © 2012 Marcilio S. S. Cunha-Filho et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [10 citations]

The following is the list of published articles that have cited the current article.

  • Román Pérez-Fernández, Mariana Landin, Samuel Seoane, Patricia Díaz-Rodríguez, Juan Sendon-Lago, and Rosalia Gallego, “Administration of the optimized β-Lapachone–poloxamer–cyclodextrin ternary system induces apoptosis, DNA damage and reduces tumor growth in a human breast adenocarcinoma xenograft mouse model,” European Journal of Pharmaceutics and Biopharmaceutics, vol. 84, no. 3, pp. 497–504, 2013. View at Publisher · View at Google Scholar
  • Seyhan I. Celikoglu, Eugene P. Goldberg, Firuz Celikoglu, Johannes Brachmann, Paul Zarogoulidis, Haidong Huang, Francis J. Turner, Kaid Darwiche, Thomas Vogl, Michael Simoff, Wolfgang Hohenforst-Schmidt, Patrick Le Pivert, Dionysios Spyratos, Konstantinos Zarogoulidis, Qiang Li, and Robert Browning, “Intratumoral chemotherapy for lung cancer: re-challenge current targeted therapies,” Drug Design Development And Therapy, vol. 7, pp. 571–583, 2013. View at Publisher · View at Google Scholar
  • Paul Zarogoulidis, Theodora Tsiouda, Antonios Sakkas, Dimitra Makrantonaki, Konstantinos Zarogoulidis, Paschalis Pavlioglou, Patrick Le Pivert, Nikolaos Machairiotis, Nikolaos Katsikogiannis, Ioanna Kougioumtzi, Konstantinos Tsimogiannis, Stylianos Kakolyris, and Nikolaos Courcoutsakis, “Current and future intratumoral targeted treatment for pancreatic cancer,” Therapeutic Delivery, vol. 5, no. 8, pp. 913–926, 2014. View at Publisher · View at Google Scholar
  • Marival Bermejo, Victor Mangas-Sanjuan, Isabel Gonzalez-Alvarez, and Marta Gonzalez-Alvarez, “Enhancing Oral Absorption of β-Lapachone: Progress Till Date,” European Journal of Drug Metabolism and Pharmacokinetics, 2016. View at Publisher · View at Google Scholar
  • Darren Svirskis, Kaushik Chandramouli, Prabhat Bhusal, Zimei Wu, Jolyene Alphonso, Joyce Chow, Divya Patel, Riddhi Ramakrishna, Seung J Yeo, Renus Stowers, Andrew Hill, Jacob Munro, Simon Young, and Manisha Sharma, “Injectable thermosensitive gelling delivery system for the sustained release of lidocaine,” Therapeutic Delivery, 2016. View at Publisher · View at Google Scholar
  • Veronica Rodriguez-Rivera, John W. Weidner, and Michael J. Yost, “Three-dimensional Biomimetic Technology: Novel Biorubber Creates Defined Micro- and Macro-scale Architectures in Collagen Hydrogels,” Jove-Journal Of Visualized Experiments, no. 108, 2016. View at Publisher · View at Google Scholar
  • Vitor Francisco Ferreira, Debora Omena Futuro, Fernando de Carvalho da Silva, Caroline Deckmann Nicoletti, and Patricia Garcia Ferreira, “Strategies for increasing the solubility and bioavailability of anticancer compounds: ß-lapachone and other naphthoquinones,” Current Pharmaceutical Design, vol. 22, no. 39, pp. 5899–5914, 2016. View at Publisher · View at Google Scholar
  • Sheng Qi, Duncan Q.M. Craig, and Esra'a Albarahmieh, “Hot melt extruded transdermal films based on amorphous solid dispersions in Eudragit RS PO: The inclusion of hydrophilic additives to develop moisture-activated release systems,” International Journal of Pharmaceutics, vol. 514, no. 1, pp. 270–281, 2016. View at Publisher · View at Google Scholar
  • Elif Sarıgöl, Melike Ekizoğlu, Sibel Bozdağ Pehlivan, Ebru Bodur, Meral Sağıroğlu, and Sema Çalış, “A thermosensitive gel loaded with an enzyme and an antibiotic drug for the treatment of periprosthetic joint infection,” Journal of Drug Delivery Science and Technology, 2017. View at Publisher · View at Google Scholar
  • Stephania G.B. Lima, Ludmila A.G. Pinho, Maíra N. Pereira, Tais Gratieri, Livia Lira Sa-Barreto, Guilherme M. Gelfuso, and Marcilio Cunha-Filho, “Preformulation studies of finasteride to design matrix systems for topical delivery,” Journal of Pharmaceutical and Biomedical Analysis, vol. 161, pp. 273–279, 2018. View at Publisher · View at Google Scholar